GenomeNet

Database: UniProt
Entry: A0A1S3L1E8_SALSA
LinkDB: A0A1S3L1E8_SALSA
Original site: A0A1S3L1E8_SALSA 
ID   A0A1S3L1E8_SALSA        Unreviewed;       970 AA.
AC   A0A1S3L1E8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 13.
DE   SubName: Full=tyrosine-protein kinase receptor UFO-like isoform X4 {ECO:0000313|RefSeq:XP_013984733.1};
GN   Name=LOC106563561 {ECO:0000313|RefSeq:XP_013984733.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013984733.1};
RN   [1] {ECO:0000313|RefSeq:XP_013984733.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013984733.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01168082};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000256|SAAS:SAAS00941529}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_013984733.1; XM_014129258.1.
DR   GeneID; 106563561; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00600564};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000256|SAAS:SAAS00601152,
KW   ECO:0000313|RefSeq:XP_013984733.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689};
KW   Receptor {ECO:0000256|SAAS:SAAS00600436,
KW   ECO:0000313|RefSeq:XP_013984733.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00601608};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    970       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010370241.
FT   DOMAIN       27    128       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      133    218       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      223    322       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      324    417       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      485    756       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      846    970       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3L1E8}.
FT   COMPBIAS    846    863       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3L1E8}.
FT   COMPBIAS    879    916       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3L1E8}.
FT   COMPBIAS    932    970       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3L1E8}.
SQ   SEQUENCE   970 AA;  107156 MW;  98E6FCBF69D353E3 CRC64;
     MNGGGGCVPL FVLLLMDIAT MLGLPVPAFQ FLKSPANVTL SLGKPVQVVC SLQGDGGGEE
     PPDVVWLRDG QSLDYADTNQ VQVPVTEGGW LTISELRIDH VKLSDIGRYC CMATVGRKDL
     MSQEGHIQLE GIPHFSVKPH DVTVAATASL SLQCLAHGPP EPVRIIWLQN GGPLNTLQDP
     VSHSPSTLNI TGLNHTSSFS CEAHNSKGVA TSASGTVTVV PSQAQKVQVV EVTNSSLHIS
     WEPGFGGVYP VSVCSIQAAL SGPDLNTLHN LLIHNQNVNV PPAQHLIPEL KPYTFYDVRV
     ACRSSQGASP WTPWVTLRTA EGVPEAAPDN VSGLFNGTDV IASWSKPPGR LNGQILGYRV
     EYLTANMSQA VMESVQSSEL AIPLSSLLDS VSLSVSACTV AGCGPWSPVQ SFKQKQPDVS
     LHQAFSWHWW KAFYPMRNAG GDFVVRYSAG RTYNRQSNEA TLSSLVISDE LKQKLQDVMV
     DSHKLTLGKT LGEGEFGSVL EGLLVHQQTV LKVAVKTMKI SICTRTEMED FLGEAACMKE
     FDHPNIMRLL GVCLQAAERG GYPSPIVLLP YMKHGDLHSF LLYSRLGDNP LSLPSQMLVK
     FMTDIARGME YLSNKRFIHR DLAARNCMLN ENMTVCVADF GLSKKIYNGD YYRQGRISKM
     PVKWIAIESL ADRVYTTKSD VWSFGVTTWE IATRGQTPYP GVENSEMYDY LRQGNRLKQP
     PGCLDIIYFL MFSCWLLSPK DRPGFPSLRC DLEKALEEMP EQEEADDLLY VNMEEPSGSL
     LGAIGGWEPF GQPHPSYWKN MGNLETIQVH HHNHHDHAER YVLCPQHEAQ PYLNDSMDNT
     QHEAQPYLND SVDSPQHKAQ PYLNDSVDSP RHEAQPYLND SMDNPQHEAQ PYLNDSVDSP
     QHEAQPYLND SVDSPQHKAQ PYLDDSVDSP QHKAQPYLND SVDSPQHKAQ PYLNDSVDRQ
     PSAQGPALSQ
//
DBGET integrated database retrieval system