ID A0A1S3L467_SALSA Unreviewed; 1000 AA.
AC A0A1S3L467;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Protein NLRC3-like {ECO:0000313|RefSeq:XP_013985757.1, ECO:0000313|RefSeq:XP_013985758.1};
GN Name=LOC106564232 {ECO:0000313|RefSeq:XP_013985757.1,
GN ECO:0000313|RefSeq:XP_013985758.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013985757.1};
RN [1] {ECO:0000313|RefSeq:XP_013985757.1, ECO:0000313|RefSeq:XP_013985758.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013985757.1,
RC ECO:0000313|RefSeq:XP_013985758.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR RefSeq; XP_013985757.1; XM_014130282.1.
DR RefSeq; XP_013985758.1; XM_014130283.1.
DR KEGG; sasa:106564232; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 183..318
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 791..1000
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 1000 AA; 113775 MW; 1BA9C5F14688AFE9 CRC64;
MADLIQRVTK VMPISDQLLQ LGMIHDEAYS NIHAAQTSQE KMRVLYKTLN TAKVKSAFYR
ILQENDPNLI QELGGPVFIE TEIIGERRVD DITQRVKEEH KASLKKKFGL VFEGTALQRT
HLNNIYRQLY ITHGESEGVN DQHEIRQIEY TPRTEKSTDT PINYNDIFKP LSGEEGETEG
SIRTVLTKGI AGIGKTFSVQ KFILDWAEEK ANQDVDLVFV LPFRELNLIK DDQYSIHGLL
NYFHPKLKEI KDAQKYADCK VMFIFDGLDE SRLPLGFHQN KKLSDLTETS SVDRLMTNLI
EGNLLPEALL WITSRPAAAN QVPHEYINKV TEVRGFNDKQ KEEYFEKNVE DEKLARKIIS
HINTSRSLHI MCHIPVFCWI TAMVLKNKLS GEITTLTEMY NHFLLVQTQL KSKKYDGKYE
MDLATIIERN KEIILKLTQL AFEQLVKGNL IFYKKDLEEC GIDVSEASVY SGFCTEILKQ
EHGLYRKKVY CFVHLSFQEF LAALYVFHCC ASKNIKALES FIADVSSELP LHELLKMMVD
KALESENGHL DLFLRFLVGI STESNQSLLQ DLLPQTEISS ETVEEIKKYL RKPNVDEVSP
DRYINLLICL TEMKDDSVHE DIDNFLKSGY GQEEKLSPTH CSALANALLM SKGVLDEVDL
RKYSISLRNR LIPAVMKCRK AKLNGCSLTE KGCEVLASAL SSNSSHLREL DLSHNDLQDS
GVKLLSAGLG NPHCQLEKLR LSFCRVTEEG CASLASALRS NPSHLRELDL SFNHPGDSGV
KLLCARLEKL DVGHNEEFWV KPQLMKTYAC DLTLDPNTAH RNLSLSEGNR RVKRVKEKQP
YPDHPERFDL VPQVLCREGL TGRCYWEVEW GGLAEIGVTY KGINRKEDGS ASDFGYNNKS
WSLACRGNHY TAFHNNEYTT IPAPHLINPP QPQRDLSSCP PHLRVGVFLD CPVGTLSFYE
IYSDTMTHVY TFQTIFTEHL YPGFGVSNEE GSSVSLSQVE
//
