ID A0A1S3L5B9_SALSA Unreviewed; 631 AA.
AC A0A1S3L5B9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ADP-ribosylation factor-binding protein GGA1-like {ECO:0000313|RefSeq:XP_013986167.1};
GN Name=LOC106564558 {ECO:0000313|RefSeq:XP_013986167.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013986167.1};
RN [1] {ECO:0000313|RefSeq:XP_013986167.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013986167.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013986167.1; XM_014130692.1.
DR AlphaFoldDB; A0A1S3L5B9; -.
DR GeneID; 106564558; -.
DR KEGG; sasa:106564558; -.
DR OrthoDB; 2917368at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR Bgee; ENSSSAG00000006354; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14239; GAT_GGA1_GGA2; 1.
DR CDD; cd17009; VHS_GGA1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF4; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 17..147
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 170..297
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 521..631
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 631
FT /evidence="ECO:0000313|RefSeq:XP_013986167.1"
SQ SEQUENCE 631 AA; 69202 MW; 965C37668D10BBF0 CRC64;
MAAPPEEESL ESRVNKATNP LNKEADWDSI QGFCEQLNNE PEGPQLATRL LAHKIQSPQE
WEAMQALMVL EMCMKNCGKR FHNEVGKFRF LNELIKVVSP KYLGTRAPEP VKKKVLEVMY
SWTVGLPDEP KIADAYQMLK KQGIVKHDPV LPDEPLPPPP PRTKSVIFED EEKSKMLSRL
LNSTHPEDLR AANKLIKEMV QEDQKRMEKV SKRVNAIQEV KESVSLLTQL LGDYSKESSS
QSNQELIKDL YQSCEKMRPT LFRLASDTED NDEALADILQ ANDSLTQVIN LYRQLVKGEE
VNGDSTAMPT LPGSSTALLD LTGLDTSPTG LPSYPDTPSL QTPSQELGIS LLDDELMSLG
LNDVTPNSTH TPQSGDWNSF QCSDSVEPVV PAVPTATVLL PAVTPIPQAP SGGPPAASPK
ALDELDLLGK TLLHQSLPPG TQHVNWDKLQ PQSRPTLRDL QTKSSTNTTS TSTPSPVLAF
PSEQPGSLLD SLPSLGPPTP APQNDISLAN VTVPLESIKP SSLLPVTVFD KHSLRVLFHF
ARDSPPSRPD VLVVIISMLS SAPIPVTNIR FQSAVPKVMK VKLQPPSGTD LPAFNPILPP
AAITQVLLLA NPHKEMVRLR YKLTFDLGEE S
//
