ID A0A1S3L5N2_SALSA Unreviewed; 630 AA.
AC A0A1S3L5N2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Kelch-like ECH-associated protein 1 {ECO:0000313|RefSeq:XP_013986100.1};
GN Name=LOC106564503 {ECO:0000313|RefSeq:XP_013986100.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013986100.1};
RN [1] {ECO:0000313|RefSeq:XP_013986100.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013986100.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the KEAP1 family.
CC {ECO:0000256|ARBA:ARBA00005288}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013986100.1; XM_014130625.1.
DR AlphaFoldDB; A0A1S3L5N2; -.
DR KEGG; sasa:106564503; -.
DR OrthoDB; 5472491at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR Bgee; ENSSSAG00000059599; Expressed in liver and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18458; BACK_KLHL19_KEAP1; 1.
DR CDD; cd18248; BTB_POZ_KLHL19_KEAP1; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR047098; KEAP1_BACK.
DR InterPro; IPR030563; KEAP1_BTB_POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF3; KELCH-LIKE PROTEIN DIABLO; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 49..121
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 630 AA; 69484 MW; 290459E0618BEE99 CRC64;
MSNECPTECK AVVTPSTRNG HRVFSYTLES HTAAAFAIMN ELRLDGQLCD VTLRVCYNDL
EAVDFVAHKV VLASSSPVFR AMFTNGLKEC GMEVVPIEGI HPRVMGRLIE FAYTASISVG
EKCVIHVMNG AVMYQIDSVV KACCDFLVTQ LDPSNAIGIA SFAEQISCTE LHQKAREYIY
MNFSQVATQE EFFNLSQCQL VTLISRDELN VRCESVVFQA CVAWVRYDRE NRRPYVQALL
QAVRCHSLTP HFLQAQLQSL EWDDQCKDYL AQIFQDLTLH KPTKVISCRT PKVPQLIYTA
GGYFRQSLSY LEAYNPCTGA WLRLADLQVP RSGLAAVVIS GLFYAVGGRN NAPDGNMDSN
TLDCYNPMNN CWLPCAPMSV PRNRIGVGVI DGMIYAVGGS HGCIHHNSVE RYDPDRDQWH
LVAPMLTRRI GVGVAVITRL LYAVGGFDGT HRLSSSECYN PERDEWKSMA AMNTVRSGAG
VCALGNRIYV MGGYDGTNQL NTVERYDVET DTWSFAASMR HRRSALGVTA HHGKIYVLGG
YDGNTFLDSV ECYDPETDTW SEVTRMMSGR SGVGVAVTME PCQKDLAQCL KHERTEVTGG
CEGGSLGCSG TGGDSGSYHN SRHGAFGKGT
//
