ID A0A1S3L6M3_SALSA Unreviewed; 1090 AA.
AC A0A1S3L6M3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 5-like isoform X2 {ECO:0000313|RefSeq:XP_013986455.1};
GN Name=LOC106564707 {ECO:0000313|RefSeq:XP_013986455.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013986455.1};
RN [1] {ECO:0000313|RefSeq:XP_013986455.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013986455.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013986455.1; XM_014130980.1.
DR AlphaFoldDB; A0A1S3L6M3; -.
DR STRING; 8030.ENSSSAP00000013146; -.
DR PaxDb; 8030-ENSSSAP00000013146; -.
DR GeneID; 106564707; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR Bgee; ENSSSAG00000005004; Expressed in head kidney and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 2.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..339
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 452..588
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT DOMAIN 610..675
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..836
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 118317 MW; 4425E90DEFF261D5 CRC64;
MPRNHSGDEG GTGLWMKTSP GHRAEGYDLK DVESGRRMMN NASAGDGLLS ASSATGAGGS
ESLRGNKGAR LSLLGKPLIY SAQSGRRNVR YRRLQNLLYN VLERPRAWAF IYHAFVFVLV
FGCLVLSVFS TIPAHQDFSS DCLLILEFVM IVVFGLEYII RIWSAGCCCR YRGWQGRLRF
ARKPFCVIDI IVLIASVAVV SAGSQGNIFA TSALRSLRFL QILRMVRMDR RGGTWKLLGS
VVYAHSKELV TAWYIGFLVL IFSSFLVYLV ENKFNSEFAT YADALWWGTI TLTTIGYGDK
TPKTWTGRML SAGFALLGIS FFALPAGILG SGFALKVQEQ HRQKHFEKRR NPAACLIQCV
WRSYAADENS VSIATWKPHL KALHTCSPTK KDQGESSTSK VLSSKQKLLR RCTLRKHTSQ
KLSFKDRVRM ASPRGQSIKS RQTSVSDRRS PGTEAGGTEG TSPAKVQKSW SFNDRTRFRP
SLRLKIQSRS TADADSNMTT EDGFGDDKGC HCEISVEDLL PSVKSVIRAV RIMKFHVAKK
KFKETLRPYD VKDVIEQYSA GHLDMLCRIK SLQTRLDMIV GPQPLSSRAK TFSSPSLPMY
YSQGRKNSTQ GVDQILGKGQ IPLDKKIRDK LLSDGDLLED MSMLGRVCKV ERQVQSIESK
LDSLLDIYRH VLRKGSSSAL TLSSLPLFEL EQTSDYQSSI LFKDHSTCST QVSSTGGGPG
IEGQRGCVTR SSTNASNLSR GLHLILAPST ELSLNLNTGT TSPSTSGPPP SSFSPSPLPQ
HHQHHHHHTL PESGEPDHRG SSSHSPPILT PNCVSGGGGF PTLARPPPPP PQPSRTVGHS
RPEREREVEV GDFCGSPEER EDDDVLGPEQ GLRIGRLGQP RGGSSGNSNG RPCNAKAEGS
WRRHTSLEME PLVPLSSALG GGGRCSSSSN PSQVDRILGK SMSVQNLGPG GSTTSRALDS
HHHPSLSLSS PSPCSSDSPT GSHSSQDPGG GGGRDGWGEE DLFISDRDVD ALPLPPEAQG
GAFGFDFLSQ GTADATSYSS ELLRTDPGLG AGLSALAGFN RSLARGSGNM SSPPSVGSTE
SLSMPHVRLK
//
