ID A0A1S3L910_SALSA Unreviewed; 2137 AA.
AC A0A1S3L910;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC106565160 {ECO:0000313|RefSeq:XP_013987442.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013987442.1};
RN [1] {ECO:0000313|RefSeq:XP_013987442.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013987442.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR RefSeq; XP_013987442.1; XM_014131967.1.
DR OrthoDB; 5478852at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13983; STKc_WNK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024678; Kinase_OSR1/WNK_CCT.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13902; SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED; 1.
DR PANTHER; PTHR13902:SF10; SERINE_THREONINE-PROTEIN KINASE WNK2; 1.
DR Pfam; PF12202; OSR1_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_013987442.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 193..451
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1586..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2024..2043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..981
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1654..1668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1776
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1915..1941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2137 AA; 228263 MW; DB2E8417DF302E9D CRC64;
MDSGDDSGSD APLGSTFSSV PNLDSDTNAN ISIYENGGER NVNNMETAAQ RGASDPSAYP
LSDYRGLVRQ RFIRRSLWFS DADDQALDAP ECVNSTPMLS VHLRTIVDRT RALGPRVAFQ
VQESSSTESQ MGQKDSATES VSADEEKERS EAEPKPEDAA APSPDTTGKA GIDENEDENE
IKAVSTSPGG RFLKFDTEIG RGSFKTVYKG LDTDTWVEVA WCELQDRKLT KAERQRFKEE
AEMLKGLQHP NIVRFYDFWE SPVKGRKCIV LVTELMTSGT LKTYLKRFKV MKPKVLRSWC
RQILKGLHFL HTRDPPIIHR DLKCDNIFIT GPTGSVKIGD LGLATLKRAS FAKSVIGTPE
FMAPEMYEEH YDEAVDVYAF GMCMLEMATS EYPYSECQNA AQIYRKVTSG VKPASYDKIS
DPEIKEIIGE CICHRREERY SIKDLLNHAF FAEDTGVRVE LAEEDDGKKS SIALKVWVED
PKKLKGKYKD SGAIEFTFDL EKETPEGVAQ EMVDSGFFLD SDVKIVGKSI KDRVALIKWR
RERTVPAVET QTQNLLQVPS MGVPRQGAQL ALAEPEEAEA DQPLTLICSL PAHATSTTSD
GGVGLMVLSN VKNGQPSAPY QSIPEPISTP QVVYSPPVQP QAQLHQGAYQ KPTAQPPQVA
YSLATTTQLH QVPYQQATIQ LHHGAYQQPK AQLHQGDYQS PPPSAGWIQA QAQAQPASAP
ATPGPPIHQN GPTAPQSFPA AAPLTTVQAQ AQPAVTAQSS HELSASQPVP QQCSDITISL
AQSAACLGSN ASTPLQQPSQ ATPPLQPLQI SSQVQSGAPQ DPHGEAQVSA PAPLHPVHPA
ILSPPWRAEL VDPEPAAAAG SDQTVPESPA RVPRLAPVPA AALKPAGIQI AAPVPDGFSL
STTQQNLDTA SMSTSYQPET SQEEPLQEKP MAFHSYPGYD SFNSDVASGK EMSDGCDGSA
SGGKGDGKTR KHHRKSARTR SRQEKTNKPK LSMLNVCNTG DKMVECQLET HNHKMVTFKF
DLDGDAPEEI AIYMVENGFI LPIEKEMFID QLKDIVDKAE DMLSENMEGE TASALGGSPQ
LGHNSGGLGG EIQQPGAHHP VYQQNVLHTG KRWFIICPVE EPPTSSQDGT TNITADGTTT
AQPDRTTIAQ PDGITVPGQS AEGGTAGTAS GRVSASSSIA NSVSGGSGGF AYEGYGLCSP
PILSSTDPLL LAMSHVPAPS GPPSVHPGPP PEGQTQSSTL PRVHHTQPAS APPVAPSGGR
RSFLSGEEHQ GGGRLGAISP IHAAQQMAEM ACTASMVEEV PCCPLVMPLS LNVSCDAQGS
STPLTPLPPQ DPSTSSAREP LQLSYPSVSR GDRSQQPVVL HQPFSSVGGA KAPSLPQSPA
PHQHTAGGPS ESDGEGRGVG GRGGFVDSTI KTLDEKLRNL LYQEYAPMYP SGTAAETPGS
GTEYVQSPPG PDSATLGSGN STPGPMGEGR YRTGEQLPQI PERMDSLSAL SDSAMCAPMS
RRKNILHSTS CSGSGSSGRS KIIIGPPDMV TRGELKQRSW SSAASPAHPA GHSDHRSSAQ
AMAMAPSTTI GRFSVVSTED DVTLRTRNSR YSAPPDFYLD TPPSMAKRGS LPRASTTTSM
SVDVTVHAHP RFLSSDSGAE SSPAKLAPAT PSRHGRSGER RGSDLMKRAV AFLRRSGRRS
SSVQSSDSPS RQGGVHGSAY VSSDNDSEME DSDMKRELTR LKEKHLKEIS ELQAHQRGEI
ELLYRRLGKA TPPPLGFSHT APPKRKSKHK HKLKAGKLLS PLVQQLKNVT TKTSDSSKTS
EPTVSLNGSP AKAPVQSDSR ARSGTSHLAT SISEPVQTQQ PCSLKGSLSS DNIYAGAGLH
GEGTGPQTPP SQGWPAYPPP PERVTYKSSS KPRARFLRST LKRLCLGKER GRGTGSGSGA
SNQPSQQQTA SSTPPPHQPI AGLAQAQANN SNNKTGTFTG TYPGAYIGSY AGSFTDDLHR
LVDDWAMEAL AVSWRPRPSS LSFSGQPRWN DDPMGPRTRA RLASAPDAPA RTAPGFEGPQ
LSLSWPMIDS QAQGSVMRTS SPGQAGFHPS YMVAHPAPDL FGGLPPSTLS PFCVSQWPEL
LSSLGSGVFA FPIVPPAWGT PTSAPPYEPP DPKTRNL
//
