ID A0A1S3L984_SALSA Unreviewed; 840 AA.
AC A0A1S3L984;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase alpha-like isoform X4 {ECO:0000313|RefSeq:XP_013987528.1};
GN Name=LOC106565195 {ECO:0000313|RefSeq:XP_013987528.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013987528.1};
RN [1] {ECO:0000313|RefSeq:XP_013987528.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013987528.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00007765}.
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DR RefSeq; XP_013987528.1; XM_014132053.1.
DR AlphaFoldDB; A0A1S3L984; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14621; R-PTPc-A-1; 1.
DR CDD; cd14623; R-PTPc-A-2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR016336; Tyr_Pase_rcpt_a/e-type.
DR InterPro; IPR027262; Tyr_Pase_rcpt_alpha.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF433; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PIRSF; PIRSF500808; PTPR_alpha; 1.
DR PIRSF; PIRSF002006; PTPR_alpha_epsilon; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|PIRSR:PIRSR002006-3};
KW Receptor {ECO:0000313|RefSeq:XP_013987528.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..840
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010299163"
FT TRANSMEM 191..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..540
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 460..531
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 571..829
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 745..820
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 31..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..129
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 481
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT ACT_SITE 770
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT BINDING 449
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 481..487
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 525
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT MOD_RES 836
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-3"
SQ SEQUENCE 840 AA; 93148 MW; 3EA4978B5FE77C4D CRC64;
MPNSLLKGSM GTCPLLLLLS VALVVSVSAQ GPSLTPTEGP VSTAKPTDSP ATTLHNVPVA
TATTPPTTAT PTAAVTTLTT TSTAEGNILT AGPSVTQAPI PPPPPPGPTI DPQVPTGATT
APQPPPAPTT VSRGGENGTT PSAPDSHTDP SPETATEPTV EATSPDTTSD TTTGGGEDDT
DQNTQSDDTP IIAVMVALSS LLVIVFIIII LYMLRFKKYK QAGSHSNSFR LTNGRSDDTE
LQSVPLLARS PSTNRKYPPL VVDKLEEDMN RRMADDNKLF REEFNALPVC PIQASCDAAS
KEENKEKNRY VNILPYDHSR VHLSSLEGVP DSDFINASFI NGYQEKNKFI AAQGPKEETV
NDFWRMIWEQ NTATIVMVTN LKERKECKCA QYWPDQGCWT YGNIRVSVED MMVLVDYTIR
KFCIQQVGDV GGKKPQRLVT QFHFTSWPDF GVPFTPIGML KFLKKVKTCN PQYSGPIVVH
CSAGVGRTGT FIVIDAMLDM MNTERKVDVF GFVTRIRAQR CQMVQTDMQY VFIFQAMLEH
YLYGDTELEV TSLESHLAKL YAPSTAGCGG MEAEFKKLTS IKIQNDKMRT GNLPANMKKN
RVLQIIPYEF NRVIIPVKRG EESTDYVNAS FIDGYRQKDS YMASQGPLQH TIEDFWRMIW
EWRSCSIVML TELEERGQEK CAQYWPSDGV MVCGDLSIEL KREEESESYT VRDLLVTNNR
ENKARAVRQF HFHGWPEVGI PSDGKGMINI IAAVQKQQQQ SGNHPITVHC SAGAGRTGTF
CALSTVLERV KAEAILDVFQ TVKSLRLQRP HMVQTLEQYE FCYKVVQEYI DAFSDYANFK
//
