ID A0A1S3LAJ6_SALSA Unreviewed; 589 AA.
AC A0A1S3LAJ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Nuclear receptor subfamily 4 group A member 1-like {ECO:0000313|RefSeq:XP_013987977.1, ECO:0000313|RefSeq:XP_013987978.1};
GN Name=LOC106565406 {ECO:0000313|RefSeq:XP_013987977.1,
GN ECO:0000313|RefSeq:XP_013987978.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013987977.1};
RN [1] {ECO:0000313|RefSeq:XP_013987977.1, ECO:0000313|RefSeq:XP_013987978.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013987977.1,
RC ECO:0000313|RefSeq:XP_013987978.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
CC subfamily. {ECO:0000256|ARBA:ARBA00006423}.
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DR RefSeq; XP_013987977.1; XM_014132502.1.
DR RefSeq; XP_013987978.1; XM_014132503.1.
DR STRING; 8030.ENSSSAP00000042988; -.
DR PaxDb; 8030-ENSSSAP00000042988; -.
DR Ensembl; ENSSSAT00000069559; ENSSSAP00000042988; ENSSSAG00000045856.
DR GeneID; 106565406; -.
DR KEGG; sasa:106565406; -.
DR OMA; FQEAAPC; -.
DR OrthoDB; 5395768at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR Bgee; ENSSSAG00000045856; Expressed in muscle tissue and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR CDD; cd07348; NR_LBD_NGFI-B; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF1; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 249..324
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 349..586
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 129..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 65043 MW; 538267209F8C6C09 CRC64;
MPCVQTQYGT VPYDNNYYSS EFLNPELSAK LTMDIGAERD QLTASSLPSI NTLVGSGYVG
EFDTYSCQIT TSASTAPSSH SAGSASSPQA QHSAFKLDDI QVYSCYPGSF ALSYLDETLS
SCGSDYYGSP ASAAPSPPTP GFQSQPGPVW DSPFSPYSPD PGCWVADKSS LAQQPSFFTF
IPTTEQHSPL GQHQGPQQSE EDPFFQPSQR HASQLHYAPL SLDQGSMDSP GLMERPMLSP
KTGSPGANEG RCAVCGDNAS CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKDCPVDKRR
RNRCQFCRFQ KCLGVGMVKE VVRTDSLKGR RGRLPSKSKT VLESVSTTPP VNIIASLVRA
HIDSNPAIGK LDYSKYQETV ASLSEKEDAN DIQQFYDLLT GTMDVIRKWA ETIPEFTAFC
PEDQELLLES AFVELFILRL AYRSSPEKDK LIFCNGVVLH RMQCVRGFGD WIDSILDFSQ
SLHRMNLDVS SFACLAALVI ITDRHGLKEP KRVEEFQNCL ITCLRDHVSS SGSDAGRPQP
NFLSRLLGKL PELRTLCTQG LQRIFYLKLE DLVPPPPIVD KIFMDTLPF
//
