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Database: UniProt
Entry: A0A1S3LB41_SALSA
LinkDB: A0A1S3LB41_SALSA
Original site: A0A1S3LB41_SALSA 
ID   A0A1S3LB41_SALSA        Unreviewed;      2718 AA.
AC   A0A1S3LB41;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 11.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 1 isoform X4 {ECO:0000313|RefSeq:XP_013988173.1};
GN   Name=LOC106565476 {ECO:0000313|RefSeq:XP_013988173.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013988173.1};
RN   [1] {ECO:0000313|RefSeq:XP_013988173.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013988173.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
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DR   RefSeq; XP_013988173.1; XM_014132698.1.
DR   GeneID; 106565476; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013988173.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2246   2268       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2280   2298       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2364   2391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2412   2434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2539   2562       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1597   1617       {ECO:0000256|SAM:Coils}.
FT   COILED     2649   2676       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2718 AA;  310142 MW;  5469A380B265C209 CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDTGDLNNPP KKFRDCLFRL
     CPMNRYSAQK QFWKAAKPGG NSTTDTVLLN KLHHAADLEK KQNDSENKKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVM LDTAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASTHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNQ EIILKGGDVV
     RLFHAEQEKF LTCDDHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVNP DYEEECLESR SSLDSEQVDL RARLRNPQEK VMYTLVSVPE
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNHPIDKEE EKPVMLRIGT
     SALKEDKEAF AIVPVSPAEV RDLDFANDAS KVLASIAGKL EKGTITQNER RAVTKLLEDL
     VFFVVDIPNN GQDVLEIMVN KPNRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE
     LADQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFRF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICNAVLDPT
     NGDILIETKL VLSRFEIEGA SIEDNSVESE EDEEEVWLFW KDRSKEIRSK SIRELAQDAK
     EGAKEDQEVV SYYRYQLNLF ARMCLDRQYL AINKISGQMD VDLILRCMSD EDLPYDLRAS
     FCRMMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD NDGTSKDEIK ECFALTMEFV
     ENYLRDVVCQ SFPFADKEKN KLTFEVVNLS RNLIYFGFYN FSDLLRLTKI LLAILDCVHV
     STIFPINKLE KGDETKGSNV MRSIHGVGEL MTQVVLRGGG FLPTTPINPP DGDQVKTQTE
     PEKQDILVMD TKLKIIEILQ FILNVRLDYR ISCLLCIFKR EFDESNSQSD LSIAGTHEGP
     NNMPGALDFE HIEEQAEGIF GGSEENTPLD LDDHGGRTFL RVLLHLTMHD YPPLVSRALH
     LLFRHFSQRQ EVLQAFKQVQ LLVTSKDVEN YKQIKSDLDQ LRSIVEKSEL WVYKRQGPDE
     GMDAGEGSAE SQHKKGDSNS GGSDKPKKPE STRSYNYRVV KEILLRLSRL CVQEGLSGRK
     SKKQQQRLLR NMGAHTVVLE LLQIPYEKGE DVRMQEIMKL AHQFLQNFCA GNQQNQALLH
     KHINLFLNPG ILEAVTMQHI FMNNFQLCSE INERVVQHFV HCIETHGRNV QYLKFLQTIV
     KAESKFIKKC QDIVMAELVN AGEDVLVFYN DRASFQTLVT MMRSERDRMD QNSPLMYHIH
     LVELLAVCTE GKNVYTEIKC NSLLPLDDIV RVVTHEDCIP EVKIAYINFL NHCYVDTEVE
     MKEIYTSNHM WKLFENFLVD ICRVSNNTSD RKHADTVLES YVTETVMSIV TTFFSSPFSD
     QSTSLQTRQP VFVQQLQAVF RVYHCNWLVP VQKGSVESCI KVLSDVAKGR AIAIPVDLDS
     QVNNLFVKSN NIVQKTAMSW RMSARNAARR DSVLTTSRDY RNIIERLQDI VSALEDRLRP
     LVQAELSVLV DVLHRPELLF PENTDSRRKC ESGGFICKLI KHTKQLLEEN EERLCIKVLQ
     TLREMMTKDR GYGEKGEALR QILVNRYYGN FHRSGGRRDS LTAFSNGTLV PVGPSKSQSG
     LGGPGALSRG EMSLAEVQCH LDKEGASDLV IDLIMNTTSD RVFQESILLA IALLEGGNTT
     IQRSFFCRLT EDKKSEKFFR VFYDRMKLAQ LEIKATVTVN TSDLGNRKRD DDAPDKEVPI
     RKKAKDSTVV VTEEAREQLL EASSATKKAF NSYRREADPE DHFSAADGTP SAGDKSQEDG
     EMSFIIVIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKNNY NLVCETLQFL DCICGSTTGG
     LGLLGLYINE KNVALINQTV ESLTEYCQGP CHENQNCIAT HESNGIDIII ALILNDINPL
     GKKRMDLVLE LKNNASKLLL AIMESRHDSE NAERILYNMR PKELVEVIKK AYLQGEVEFE
     DPEEDDDSGE EEEHDAASPR NVGHNIYILA HQLARHNKEL QVMLKPGGTN GEGDEALEFY
     AKHTAQIEIV RHDRTMEEIV FPVPNICEFL TCESKLRVYY TTERDEQGSK INDFFLSAED
     LFNEMNWQKK LRAQPVLYWC SRNMSFWSNI SFNLAVLMNL LVAFFYPLEG LREGTLEPHL
     SALLWVGMLA LLAIVVAMPQ PLGVRTLIIA TILRLIFSVG LQPTLFLLGA FNVCNKTIFL
     MSFVGNRGTF TRGYKAMILD VEFLYHLMYL IICSLGVFVH VFFYSLLLFD LVYREETLLN
     VIKSVTRNGR SIVLTAVLAL ILVYLFSIVG YIFFKDDFIL EVDRIPNTTL ENGASVANEL
     VSAGMCQSET GENNCTTELQ VEDFVEDMED GKERTCDSLL MCIVTVLSHG LRSGGGVGDV
     LRKPSKEEPL FAARVIYDLL FFFMVIIIVL NLIFGVIIDT FADLRSEKQK KEEVLKTTCF
     ICGLERDKFD NKTVTFEEHI KEEHNMWHYL FFIVLVKVKD STEYTGPESY VAEMIKEHNL
     DWFPRMRAMS LVSSDAEGEQ NEIRNLQEKL ESAMRLVCNL SGQLTELKEQ MTEQRKQKQR
     IGLLGHPPHM NVNPQQPA
//
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