ID A0A1S3LC23_SALSA Unreviewed; 649 AA.
AC A0A1S3LC23;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X1 {ECO:0000313|RefSeq:XP_013988506.1};
GN Name=LOC106565672 {ECO:0000313|RefSeq:XP_013988506.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013988506.1};
RN [1] {ECO:0000313|RefSeq:XP_013988506.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013988506.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR RefSeq; XP_013988506.1; XM_014133031.1.
DR AlphaFoldDB; A0A1S3LC23; -.
DR STRING; 8030.ENSSSAP00000106070; -.
DR PaxDb; 8030-ENSSSAP00000106070; -.
DR Ensembl; ENSSSAT00000140792; ENSSSAP00000106070; ENSSSAG00000076529.
DR GeneID; 106565672; -.
DR KEGG; sasa:106565672; -.
DR OMA; TKWPEED; -.
DR OrthoDB; 2997036at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR Bgee; ENSSSAG00000076529; Expressed in mesonephros and 9 other cell types or tissues.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF22; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|RefSeq:XP_013988506.1};
KW Receptor {ECO:0000313|RefSeq:XP_013988506.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|RefSeq:XP_013988506.1}.
FT DOMAIN 502..561
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 220..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..259
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 73741 MW; 21FC0F3F0353A20D CRC64;
MYRSDSPYGL DSSSYAGSVQ SVQSNGYSVD DRLSQISNLS RPSAKSIYMQ RKEYADSITK
MMNKFQYRVE HLFTCDLDGR EVRDVNDCVE RLKLLDGMGR VWGQDMVLEV RDGNLLLTDI
ETKEELESLP LSSIVELKAV MDSCVYNSLL TATVKDRSRR TTSVFMFQCE DLRADFIKRD
LERVLPHQRD DVSNHSDNSR SNQEVMAGHQ IVRNLQNAVP PPEQREWTPP EDPSAQWSAP
DYDEDPTPVP TPTPPMPREE PLPPRKETPV QHLFTEEEPE PAPVSPPRPY TETDRNVDIV
NHIFNDIEIF MGQVAAAAAK AEKKKKKKNK NKDKGIKGMP PAEEFETCLQ KIKCGFNLLG
ELNGKISNPS APEFVHCLFS TLAFVVSHSP EELPPTIVVP LLKPECIRLL SGEATPEEDQ
LWQSLGDAWN VPSTKWPEDD EDIPTYTLEF HDGWQPLELT HSLPGREPER REQSQKQSQS
PRSTPEKRSA PFKPPPSRPD EPNLRNIRVM YDFTARNNRE LSISKGEVVQ LLDMSKKWWQ
VRNNRGEEGF VPNNVLESQD KEQEKQETSG PPSLTKRSKP DQVKAWLEYK GFSKITVRCL
GVVSGSMLLG MTREELKIVC PEEGGRVFFQ LQNIKSAMAL ASEVRPIEP
//
