ID A0A1S3LCF7_SALSA Unreviewed; 449 AA.
AC A0A1S3LCF7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase {ECO:0000256|ARBA:ARBA00038854};
DE EC=2.4.2.42 {ECO:0000256|ARBA:ARBA00038854};
GN Name=LOC106565732 {ECO:0000313|RefSeq:XP_013988641.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013988641.1};
RN [1] {ECO:0000313|RefSeq:XP_013988641.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013988641.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Glycosyltransferase which elongates the O-linked glucose
CC attached to EGF-like repeats in the extracellular domain of Notch
CC proteins by catalyzing the addition of xylose.
CC {ECO:0000256|ARBA:ARBA00037301}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-
CC alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-
CC seryl-[EGF-like domain protein] + H(+) + UDP; Xref=Rhea:RHEA:56064,
CC Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:14611, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57632, ChEBI:CHEBI:58223, ChEBI:CHEBI:140575,
CC ChEBI:CHEBI:140576; EC=2.4.2.42;
CC Evidence={ECO:0000256|ARBA:ARBA00035950};
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DR RefSeq; XP_013988641.1; XM_014133166.1.
DR AlphaFoldDB; A0A1S3LCF7; -.
DR GeneID; 106565732; -.
DR KEGG; sasa:106565732; -.
DR CTD; 727936; -.
DR OrthoDB; 5401138at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:UniProt.
DR CDD; cd06430; GT8_like_2; 1.
DR InterPro; IPR002495; Glyco_trans_8.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR46012:SF1; GLUCOSIDE XYLOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR46012; IP22168P; 1.
DR Pfam; PF01501; Glyco_transf_8; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..449
FT /note="UDP-D-xylose:beta-D-glucoside alpha-1,3-D-
FT xylosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010233736"
FT REGION 79..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 51702 MW; 7664BD432208E9CC CRC64;
MRIHCKIVVI AVCFGVFLLL YFFGGNAADD PPLKEVEEDN YFPKFSGLRN NVASKLTKKT
PDELHIPHKQ PLTYRKVSKV ASRGGNAIAK SRQRSDMGVG RPASKRARAD EVMHLAVVAC
GNRLDETLTM VKSALLFSIK SIKFHIFAED PLTSQFEKGF LFQLSQWPHA ITNKFQYSIY
PITFSVGNAE EWKKLFKPCA AQRLFLPVIL KDVDSLLYVD TDVLFLRPMD DMWSFLKAFN
TTQLAAMAPE HEIPKIGWYS RFARHPFYGV TGVNSGVMLM NLTRIRSTLF KNSMIPSGLS
WEDLLHPLYQ KYKNHITWGD QDLLNIIFHY NSECLYTFPC QWNYRPDHCM YGSNCKGAEE
EGVSILHGNR GVYHDDKQPA FKVVYDAIHE YPFEDNLFQS LFYPLQTKFL DTVNTLCGRI
PQVFLKQVEK SMRTVYEKKV VRHVRPPPK
//
