ID A0A1S3LD14_SALSA Unreviewed; 4208 AA.
AC A0A1S3LD14;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dynein heavy chain 1, axonemal isoform X2 {ECO:0000313|RefSeq:XP_013988848.1};
GN Name=dnah1 {ECO:0000313|RefSeq:XP_013988848.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013988848.1};
RN [1] {ECO:0000313|RefSeq:XP_013988848.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013988848.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_013988848.1; XM_014133373.1.
DR STRING; 8030.ENSSSAP00000118268; -.
DR PaxDb; 8030-ENSSSAP00000118268; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 970..1372
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1500..1826
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1994..2114
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2355..2450
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2499..2760
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2774..3119
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3147..3368
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3612..3725
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3758..3896
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3902..4204
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 790..848
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3003..3037
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4208 AA; 478782 MW; 1ED061B1212AC4D6 CRC64;
MEAKQVPQNH PHGVGVFVPH APSKLAEHKL PPLQSHRSKL PPVRKYPVIE QKGYYSELIT
TAAKPHLQSC TDGPETQQSL LCQAGYESNT PKVTTFRTPS DLHSLVERDK HGPTTQHQQH
TDFSTGGYTA KVQLPYHSLP GQHLRKIEIE RRRREYLKLD IAQLLTEQGI DSNLLMPRHH
SIEEHVTTPE NPLPPVSNYL PLEVFDNEEF DCRTPQDWLA LGYENGSTDH KPIPAKALLP
TTDKIPPEDP KSPNLEYSWQ FVGVLDYNQE KGLYLVQKAD KNGRVRDANG KPVLNEGQRT
IGVFLLSATQ YWISRIRLLF SAEDPRLFSQ RVQFAQRCRE NTEALLLYHL SVDCMPVWSG
TSSLNAQSLA RVKEHALSTP GLRLKLLQEC IVRLEKEINL EYDRTMNRIS FDRVVLTNPE
DFSHITLPQR EPERVPQNGF VSVPTYPFEK NRAAFAFNSL LTKPEVISAL SKVRGECNRV
AAMSLFHVTF TKSLRLEEFE LTQSQTHAQV QLFLRDSWVT TLCKGIHTSL RDVGPGWFSL
TESRWEVYRM SKLCSLMALV RYSLQDSLRF LVQDSLVSLT QLLLDACHSV LHCPQDLTWG
SNLINSPYKP KKSPLFLVDL VLDVTGVHYS TPLENFETSI ITLFDKGILS THNVPQLDKF
VMQKMFISGT PLLESVGLWE PAVAELRERV RAALRQAAIP LRAYAREYER YLELHNSDIE
TFLKAHSQEE QTPQEVKREV VQHLKEKERL DHSFPSSIVI GPFTVSVESV RQSLSKKRRA
LANAVLDRLA LKLRKQVEDA CEECKAISRK LHEKPNSIEE LTDQREWMKQ ISDQLKAHEE
LLSKAMSDYE LIDEFFYTLS NEDFNGKWTA IGWPHKIVTQ METVSSQHVE DEERFNKIQQ
ADQNNFQERL DSLQMVVAGF SGYTDISRAH EVANEVRRVG KQLKESQTMA QTYNNRDRLF
GIPVTNYDRL QKLIRDFQPF RDLWTTTSDW LRWHDSWHND PLSIIDPEQL ERNVTDAFKT
MHKCVKMFKD IPACQEVASD IRGKIDDFRP YIPLIQGLRN PGMRGRHWQL LSDRIHMNVK
PKANLTFSRC LELGLQDHVD EIAQVAEVAG KEYAIEQALD KMEHEWSTVT FEVLPYKETG
TYILKSPDEA SQLLDDHIVM TQSMSFSPYK KPFEERISTW ESKLRMTQDV LEEWLTCQRS
WLYLEPIFSS DDINRQLPVE GKRYQTMERT WRKVMKSAYD NKQVIDLCPD PRLLDSLRDC
NKLLELVQKG LSDYLETKRG SFPRFYFLSD DELLEILSQT KDPTAVQPHL RKCFENIARL
KFQSDLQITH MYSGEGEEVK LCLPVWPSGN VEDWLREVEK SMKACLRDNI ERSLKVYPQQ
PRTEWVLSWP GQVVIAGCQT FWTTEVSNAL EQGDLTDRLY PQLQTQLGDL VQLVRGRLSK
MQRAVLSALI VIEVHAKDVA AKLVEEGVSS INDFEWISQL RYYWARNDLY IRAVNAEFLY
GYEYLGNSGR LVITPLTDRC YLTLTGALHL KFGGAPAGPA GTGKTETTKD LGKALAIQTV
VFNCSDQLDF IAMGKFLKGL ASSGAWACFD EFNRIDVEVL SVVAQQIATI NKAQHQRAER
FVFEGQEIPL VASCAVFITM NPGYAGRTEL PDNLKALFRP VAMMVPDYAM IAEISLYSFG
FSDAKVLSKK ITTTFKLSSE QLSSQDHYDF GMRAVKTVIS AAGNLKRENQ DMNEELICLR
AIRDVNVPKF LQDDLKLFNG IVSDLFPKIR EEPIDYGILE KSIRNVCAKK NLKDVDGYIT
KCIQLYETTV VRHGLMLVGP SGSGKTKCYE ILGTAMTALQ GQVSVSGGVY EAVQTYVLNP
KSITMGQLYG EFDLLTHEWS DGILSSLIRG GSSSMDEEKK WYMFDGPVDA VWIENMNTVL
DDNKKLCLSS GEIIKLTDVQ TMMFEVQDLA VASPATVSRC GMVYLEPSIL GLAPFTECWL
RTVPEPLRPY TDQLNSLFIR FLQDSITFVR KSVKEVIFSM DSNLTCSLLK LLDCFFQPFI
HREGERPLLQ EKLDRLKELI EPWFIFSLVW SVGATGDAPS CQRFSAWLRA KMAEEKVELC
FPEEGLVYDF QLDDAGISNM GDEEEEDRGR KVHWVSWMKS AQNVVITPET SYSDIIVPTP
DTVRISFLMD MLLSNKKPVL CIGPTGTGKT LTMSDKLLKN MPAEYITHFL MFSARTSANQ
TQDYIDSKLD KRRKGVFGPP LGKYFIFFID DLNMPILETY GAQPPIELLR QWMDHGGWYD
RKQIGTFKHL VDINFACAMG PPGGGRNPIT QRFTRHFNFL SFTEMEDASK KKIFSTILGN
WMGPVPEIQP LNGPLVDATI RVYATITSQL LPTPAKSHYT FNLRDLSKVF QGILMAEATK
IEDKMHLLQL WYHESCRVFQ DRLVSAEDRD WFDKLLQARI EEFGCSFEDA VPCQPVLFGD
FMIPGADNKA YQLIEDKEKL ARVMEEYMDD YNQISTTKMK LVLFMDAIQH VCRISRILRQ
PLGNALLLGV GGSGRQSLTK LATHMSDYEC FQIELAKNYG HTEWREDLKS IMLKAGLQNV
QITFLFVDTQ IKSESFLEDV NNILNSGDVP NLYAVDEQER ILTAMKPVVQ DLGQQPTKAN
LMAAYIKRVR SNIHTVLCMS PIGEVFRARL RQFPSLVTCC TIDWFSAWPE EALQSVAASF
LYELPELEAS PTAMKGLIMM CMEIHQMVAR KCAQYLAELS RYNYVTPKSY LELLAIFSSL
IGRKKQELHS ARQRMKTGLD KLLRTAEDVS KMQEELETMR PLLEEAAKDT VITMEKIKVD
TVVAEETRTA VQAEEAKASQ KACVAGAIAE DAQKDLDEAL PALDAALTSL KSLNKNDVVE
VRAMQRPPHG VKLVIEAVCI MRSIKPKKVA GEKPGTKVDD YWEPGKSLLQ DPGKFLEGLF
KFDKENIPDS VIKLVQPYID NEEFQPANIA KVSKACTSIC QWVRAMHVYH FVAKGVEPKR
KALQEAQEDL AATQLILDDA NEKLAQVEEG IATLQGKYHD CLAKRDELDN KCQLCENRLV
RADKLIGGLA DEKVRWRETV QHLEYMVNNV SGDVLLAAGY VAYLGPFTGE YRASMADEWL
RGFKEQGVPH TEEPNLISTL GDKVKIRSWQ ITGLPKDNLS VENGVITQYS QRWALFIDPQ
GQANKWVKNM ERDNGLDVMK LSDRDFLRSL ENAIRFGKPC LLENVGEELD PALEPVLLRQ
TFKQQGSTVL KLGDAVIPYH DDFKMYITTK LPNPHYSPEI STKVTLINFT LSPSGLEDQL
LGRVVAEERP DLEEAKNQLI VSNARMKQEL KEIEDQILFR LSSSEGNPVD DEELIRVLGA
SKIKAGEIQA KVMVAEETER DIDATRLEYV PVAVRTQILF FCVSDLSNVD PMYQYSLEWF
LGIFMSGIAN SERADTVEQR IININEFFTF SLYSNVCRSL FEKHKLMFAF LLCARIMMNE
NKIDMSEWRY LLAGGMPQQQ LSNPAVRWLS ERAWQDILGL SALPTFNSLA DSFPKHMKAF
KRIFDSSEPN REPVPGEWNT QLDSFQKLLI LRCLRADRMT HGLQDFVAAQ LGQRFIEPQA
SDLSVVFKES SPSTPLIFVL SPGTDPAADL YKFADVMKFS KKMSAISLGQ GQGPWAEAMM
HSAMERGKWV FFQNCHLAPS WMPSMERLIE NIDPDKVHRD FRLWLTSLPS NKFPVSILQN
GSKMTIEPPR GIKANLLKTY LSLNDDFITT CTRAAELKSL LLSLCLFHGN AIERRKFGPL
GFNIPYEFTD GDLRICISQL KMFLDEYQDI PYKVLKYTAG EINYGGRVTD DWDRRCILNV
LEDFYCPAVL GTDYAYSASG VYRQIDTELD IKGYLAYIRG LPINDTPEIF GLHDNANISF
AQNEAFALLG AVVQLQPKAA ASGGKAREEI VEEIVAGIVE KVPQPISVQE VMTKYPVQYE
ESMNTVLIQE VIRYNRLLVV ISQSLSDIVK ALKGLVVMSS ELELMANSLF INKVPDMWQA
KAYPSLKPLA SWVSDLLQRI KFLHGWISDG VPPVFWISGF FFPQAFLTGT LQNFARRSVV
SIDTIGFDFR VMRESASALK ERPEMGCYIH GLFLEGARWD AKVGRLTESR PKELYTEMAV
IWMVPEPNRK PPTSGVYICP IYKTLTRAGT LSTTGHSTNY VIAVELPTHT TQRYWIKQGV
ALICALDY
//
