ID A0A1S3LEV3_SALSA Unreviewed; 361 AA.
AC A0A1S3LEV3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN Name=LOC106566158 {ECO:0000313|RefSeq:XP_013989493.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013989493.1};
RN [1] {ECO:0000313|RefSeq:XP_013989493.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013989493.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR RefSeq; XP_013989493.1; XM_014134018.1.
DR AlphaFoldDB; A0A1S3LEV3; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SMART; SM00248; ANK; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT REPEAT 275..295
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 361 AA; 39977 MW; 1D0812E2273135CF CRC64;
MEPSGLKFNK LYLDEEDKPH NPMVNAGAIV ISSLIKPGSN KAEKFDYVMD FIKKMAGQEY
VGFSNATFQS EKETGDRNFA IGYYLKEKKC FPRGAEMIDA LDFYFQLCSI EVTCESGSVM
AATLAHGGIC PITGERVLSA EAVRNTLSLM HSCGMYDFSG QMAFHVGLPA KSGVSGAVLL
VVPNVMGVMC WSPPLDKVGN SVRGIHFCQE LVSSFNFHNY DNLRHFVKKQ DPRRQDGDDR
NKSVVNLMFA AYSGDVSALR RFALSSMDME LKDYDSRTAL HVAAAEGHVD VVRFLTDTCK
VNPFVKDRWS SIPLDDALQF GHGAVVNVLQ EYQVACQEQD RLPVAEIIPI PPKLETVEGM
V
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