ID A0A1S3LHS9_SALSA Unreviewed; 526 AA.
AC A0A1S3LHS9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Acid-sensing ion channel 1-like isoform X1 {ECO:0000313|RefSeq:XP_013990496.1};
GN Name=LOC106566712 {ECO:0000313|RefSeq:XP_013990496.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013990496.1};
RN [1] {ECO:0000313|RefSeq:XP_013990496.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013990496.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC1 subfamily. {ECO:0000256|ARBA:ARBA00038517}.
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DR RefSeq; XP_013990496.1; XM_014135021.1.
DR AlphaFoldDB; A0A1S3LHS9; -.
DR GeneID; 106566712; -.
DR KEGG; sasa:106566712; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 2.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF170; ACID-SENSING ION CHANNEL 1; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 44..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 526 AA; 60518 MW; 0B80BB04F135B98E CRC64;
MELKVESEEM DCNQPPPVEA FAQNSTLHGI SHIFTYERVC IKRCLWVVFF LGSLTFLLFV
CVDRIHFYLE YPHVTKLDEI STPVMVFPAV TFCNLNSFRF SRVTRNDLYH AGELLALLNQ
RYEIRDTHLV EESVLETLKV KADFHNFKPR PFNMREFYDR TGHDIKEILL ACHFRGAECR
AEDFQVVFTR YGKCYTFNAG GEGRTPLITT KGGMGNGLEL MLDIQQDEYL PVWGETDETS
FEAGIKVQIH NQEEPPFIDQ LGFGVAPGFQ TFVSCQEQRL IYLPPPWGDC KVTWMDSEFF
ETYSITACRI DCETRYLVEN CNCRMVHMPG DAPYCTPELY KECADPALDF LVERDNDFCV
CETPCNMTRY SKELSFVKIP SKASAKYLAK KYNKSEQYIA DNILVLDIFF EALNYETIEQ
KKAYEVAGLL GDIGGQMGLF IGASILTILE LFDYIYEVIK YKLCRCSEKK HKHSNNNDQG
AVLSLDDVKC HGGATQRTSP AEPIRTQGSK KMEHFNLIQK WTDVRV
//
