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Database: UniProt
Entry: A0A1S3LI64_SALSA
LinkDB: A0A1S3LI64_SALSA
Original site: A0A1S3LI64_SALSA 
ID   A0A1S3LI64_SALSA        Unreviewed;       362 AA.
AC   A0A1S3LI64;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=LOC106566776 {ECO:0000313|RefSeq:XP_013990638.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013990638.1};
RN   [1] {ECO:0000313|RefSeq:XP_013990638.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013990638.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   RefSeq; XP_013990638.1; XM_014135163.1.
DR   GeneID; 106566776; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR027260; Hyaluronidase-3.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   PANTHER; PTHR11769:SF19; PTHR11769:SF19; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    362       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010244642.
FT   ACT_SITE    143    143       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID    219    235       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   362 AA;  40933 MW;  FE4E3615D4EB132A CRC64;
     MLLRSFPLTI LLLCTIPVTP QWGPVGDESG GSVAAAGPVV QGRPFTMVWN MPTARCQEHY
     GIHLDLGAFD IVENHHQRFQ GQNMSIFYHN QLGLYPYISQ EGLQVNGGVP QRGDLEAHLA
     LAKTQISALL RTRFSGLAVI DWEEWRPLWV RDFGIKLEYR RLSKKLVRGE HPELTKQEVN
     SLARKEFERG ARAFMSETLQ LGVCLRPRGL WGFYSFPECF NNHRKQKGHS YTGHCHSKTR
     QKNDQLAWLW RQSTALYPSI YLPQHLAGSS DASLLVRHRL LEALRVANQY PTSTHATPVL
     PYARVAFAHT FHFLNKTDLE HTLGESAALG MAGVVLWGEQ AFAKSKVRSG RPHSLCIGSV
     RY
//
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