ID A0A1S3LIB5_SALSA Unreviewed; 699 AA.
AC A0A1S3LIB5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Propionate--CoA ligase {ECO:0000256|ARBA:ARBA00029726};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.17 {ECO:0000256|ARBA:ARBA00012985};
GN Name=LOC106566799 {ECO:0000313|RefSeq:XP_013990682.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013990682.1};
RN [1] {ECO:0000313|RefSeq:XP_013990682.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013990682.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA;
CC Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392,
CC ChEBI:CHEBI:456215; EC=6.2.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR RefSeq; XP_013990682.1; XM_014135207.1.
DR AlphaFoldDB; A0A1S3LIB5; -.
DR Ensembl; ENSSSAT00000217157; ENSSSAP00000173034; ENSSSAG00000075232.
DR GeneID; 106566799; -.
DR KEGG; sasa:106566799; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR Bgee; ENSSSAG00000075232; Expressed in digestive tract and 16 other cell types or tissues.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF126; ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 30..90
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 98..526
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 581..659
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 699 AA; 78813 MW; EFDB3A598F6C2E8F CRC64;
MIPDKAPKED VFHAGGDLKK EAHVPNFEKY KELYLKSIEH PDEFWGDIAK DFYWKSKHTG
QFMDYNFDVT KGEIYIKCME GATTNICYNV LDCNVHERRL GDKVAFYWEG NEPGDEMTVT
YRELLQQVCQ FANVLKSQGV KKGDRVSIYM PMVVELVVAM LACVRIGAVH SIVFAGFSAE
SLCERILDSQ CSLLITADGF YRGDKLINLK VIADDALQKC RDRSFPVQRC IMLKHLSKEV
EAIPLSSQSP PAKRPCPDLQ QEKQKDRVKK IRPVPQVPWN PEVDQCWLSL LSGVSEECEP
EWCDSEDPLF ILYTSGSTGK PKGVLHTIGG YMLYVATTFK LVFDYHPDDV YWCTADIGWI
TGHSYITYGP LANGATSVLF EGLPTYPDVS RMWEIVDKYQ VTKFYTAPTA IRLLMKYGCE
PVQKYKRDSL KVLGTVGEPI NPEAWQWYYS VVGEKRCPVV DTFWQTETGG HVLTPLPAAT
PMKPGSATFP FFGVVPAILN ESGEELEGPS EGYLVFKQPW PGVMRTVYGN HQRFETTYFE
QFPGYYVTGD GCRRDKDGYY WITGRIDDML NVSGHLLSTA EVESALVEHE AVVEAAVVSR
PHPVKGESLY CFVTLTDGVS FSRTLEAQLK KQVREKIGAI ATPDFIQNAP GLPKTRSGKI
MRRVLRKIAR NERDLGDVST LADSSVIELL FQNRCCGAV
//
