ID A0A1S3LIL6_SALSA Unreviewed; 738 AA.
AC A0A1S3LIL6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN Name=LOC106566847 {ECO:0000313|RefSeq:XP_013990798.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013990798.1};
RN [1] {ECO:0000313|RefSeq:XP_013990798.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013990798.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013990798.1; XM_014135323.1.
DR AlphaFoldDB; A0A1S3LIL6; -.
DR GeneID; 106566847; -.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000087266; Chromosome ssa13.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF1; AMP DEAMINASE 1; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
SQ SEQUENCE 738 AA; 85662 MW; 0DDEA29D28218ECE CRC64;
MPKVNMPETD EHMRAFAEEV FASETKGEGV RDEISLFEEQ DDCPILKQEM AYHLHTEEDI
EKRKKRLQKS RIMTLPPSMS DQARKVLAPV AEVLLDTPTY LEVPDFQRVA IIGDYASGVT
MDDFEISCKG VYRALTIREK YMRLAYQRFP LTTSQYLRDI EGEPFKPEHS VQPVFTSPPK
EGEDPFNTKC LPENLSWVAR MKDGVIYVYK DAAEADQHKP IENMPAPHYE TFIDDMNFLI
ALIAQGPTKT YSHRRLKFLM SKFNVHEMLN EMEEMKELKL NPHRDFYNCR KVDTHIHAAA
CMNQKHLLRF IKKSYRVDAD RVVQNIKGKD VTMKELFANL NLHPYDLTVD SLDVHAGRQT
FQRFDKFNAK YNPVGASELR DLYMKTENHI DGEYFARIIK EVASDLEDAR YQYAEPRLSI
YGCKPNEWAK LSGWFNKHRV FSPQLKWMIQ VPRIYDIFRG RNFVPHFGKM LENIFMPIFQ
ATIEPHANPE LSIFLKHVTG FDSVDDESKH SGHMFCTKSP KPEEWDIVKN PSYSYYIYYM
YANITMINHL RKARGMNTFQ FRPHCGEAGA VTHLLASFMT ADNISHGLNL KKSPVLQYLY
FLAQIPIAMS PLSNNSLFLE YAKNPVLEFL KKGLIVSLST DDPMQFHYTK EPLMEEYAIA
AQVFKLSTCD MCEISRNSVL QSGLSDEEKT HFLGADYLKE GPEGNDIRKT NVAQIRMAYR
YETLCYELNL IKEGLKTD
//
