ID A0A1S3LKY2_SALSA Unreviewed; 768 AA.
AC A0A1S3LKY2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN Name=LOC106567160 {ECO:0000313|RefSeq:XP_013991620.1,
GN ECO:0000313|RefSeq:XP_013991621.1, ECO:0000313|RefSeq:XP_013991622.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013991622.1};
RN [1] {ECO:0000313|RefSeq:XP_013991620.1, ECO:0000313|RefSeq:XP_013991621.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013991620.1,
RC ECO:0000313|RefSeq:XP_013991621.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC chloride anion transport in an alternate-access mechanism where a
CC saturable binding site is alternately exposed to either one or the
CC other side of the membrane. Also acts as a DIDS- and
CC thiosulfate- sensitive anion exchanger the exchange of chloride for
CC bicarbonate ions across the cell membrane.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_013991620.1; XM_014136145.1.
DR RefSeq; XP_013991621.1; XM_014136146.1.
DR RefSeq; XP_013991622.1; XM_014136147.1.
DR STRING; 8030.ENSSSAP00000101572; -.
DR PaxDb; 8030-ENSSSAP00000101572; -.
DR GeneID; 106567160; -.
DR KEGG; sasa:106567160; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR Bgee; ENSSSAG00000074870; Expressed in actinopterygian pyloric caecum and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 172..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 206..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 244..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 280..299
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 333..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 370..394
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 470..495
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 519..731
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 574..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 85178 MW; 5383FE0074856878 CRC64;
MQQERPRYVI NRLAYSLPDF DGEFDKKKRA FPIGEKVKKC FRCSGSRLKS LLFRHLPILS
WLPKYKVKEN LLCDVISGVS AGTIQVPQGM AFALLANLPP VNGLYSSFFP LIPYFFMGTA
HQMVPGTFAV LSIMVGMVCL SLAPESDFSH FNATLNATVV DEDRMNEVRL GISGTLACLT
AIIQMGLGLM QFGFVAIYLS ESFVRGFMTA AGLQILISVL KYIFGIKVPP YSGPLATIYT
LKDIFYGLPD TNIASLVFAL VSSVVLITVK ELSAHYRHKL PFPIPMEIIV VVVATAISGP
LDLPKKYHMD IVGEIPLGFP APILPTVIQW DDMLSTAFSL AIVGYVINLA MGRTLAAKHG
YDVDPNQEML ALGCSNFLGS FFKIHVICCA LSVTLAVDNA GGTSQFASLC VMLVVMVTML
ALGAFLKPLP KSVLGALIAI NLKNTLLQLS DPYYLWKKSK LDCCVWVVSF LATFFLSLPY
GVAIGVSFSI LVVVFQTQFR NGSEMAQIMD TDLYKNPKIY SKVKCVEGVK IVNYCSPLYF
ANAEIFRQKV IKKTGLDPSK LLLARKKFLK KQQKELEGQN KKTKKKKPCS LGTMKSQTIS
QIELQNDFDD SNPYPPPSPV SYVNFHCSDI ELGEQPPDPE QPSSSPVTLD SQPRPFHTLI
LDMAGVCFID LMGIKVLIKM NSSYEMLGIK LYLANVQAQV YEELEGGGVF EEGNIAQGHL
FLSVHDAILC AQQRSRNTEN SEKTEKERKE LVFNIQEDEE RDLEQELF
//
