ID A0A1S3LL49_SALSA Unreviewed; 780 AA.
AC A0A1S3LL49;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=LOC106567004 {ECO:0000313|RefSeq:XP_013991238.1,
GN ECO:0000313|RefSeq:XP_013991239.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013991239.1};
RN [1] {ECO:0000313|RefSeq:XP_013991238.1, ECO:0000313|RefSeq:XP_013991239.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013991238.1,
RC ECO:0000313|RefSeq:XP_013991239.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013991238.1; XM_014135763.1.
DR RefSeq; XP_013991239.1; XM_014135764.1.
DR STRING; 8030.ENSSSAP00000118040; -.
DR PaxDb; 8030-ENSSSAP00000118040; -.
DR Ensembl; ENSSSAT00000234268; ENSSSAP00000138321; ENSSSAG00000080589.
DR GeneID; 106567004; -.
DR KEGG; sasa:106567004; -.
DR CTD; 6778; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR Bgee; ENSSSAG00000080589; Expressed in head kidney and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16856; STAT6_CCD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF66; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 566..662
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 743..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 158..185
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 780 AA; 88712 MW; C35C9E8C5345F9FF CRC64;
MAQWTQMKQL IPYLATQTLN ELYSPSFPMD VRCYLANWIE EQRWEDFEPE KVDQEPQALT
LLDQIISCLQ NLAGQNPNVV ERMRLQHISR NMNMFRSQPF QLVLTVRDVL RKERELLSQA
STQIPALALF SQPPAQDSMA AAPPTRDVDL LVLKVLEIQD CRQQIHQLQE ELNWERQNYE
SMQGTLQQTQ TNGMDSSISE VTKLQTNIKQ HEYNGQVIAK KRVQLLQEAV SSLEKCQSRL
ISRIKAWRWE QHQATIGHPF DDNLSPLQTW CEQLLGVNGK LRQEVMLAGE PIPELQERLG
RLLQTLIQSS LMVDKQPPQV IKTQSKFSTT VRYLLGEKVA PGKPVLFKAQ IITEAQARNL
GQLGSVPSEN VGELINNTAI LEHNTSSKST CATFRNMSIK KIKRADRKGS ESVTEEKFAL
FFTTEISITG CDIPYRIQMI SVPVVVIVHG SQDNNALATI IWDCAFSEPE RIPFLVPERV
PWKQMCRTLN SKFMSEVGTQ RCLDNYNQHF LAQKIFDKPD IAGDYSNMLV SWAQFNKEVL
PGRPFTFWQW FDGVIELTKK HLKSYWSDGL IFGFIGKQHL HLILKDRPNG TFLLRFSDSE
IGGITIAYVA PSENGGQKIQ NIQPSTKRDL EIRSLGDRIQ DIDFITHVYP DLPKNDVFRK
YYTDNPLPRD TTSGYLVVSI QTKVGVEAHC DSPQRSETPH ENNSSFYSMD QGNGASASPF
YSLSPNNQFQ TPFQLAPVPL QGGMYSDPLS NPNGLFPGPD MSQGPTTEME LEEILNTLSE
//
