ID A0A1S3LL71_SALSA Unreviewed; 1527 AA.
AC A0A1S3LL71;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN Name=LOC106567215 {ECO:0000313|RefSeq:XP_013991717.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013991717.1};
RN [1] {ECO:0000313|RefSeq:XP_013991717.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013991717.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR RefSeq; XP_013991717.1; XM_014136242.1.
DR STRING; 8030.ENSSSAP00000058197; -.
DR PaxDb; 8030-ENSSSAP00000058197; -.
DR GeneID; 106567215; -.
DR OrthoDB; 2904336at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR Bgee; ENSSSAG00000052989; Expressed in sexually immature organism and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.10.720.50; PWWP, helical domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025766; ADD.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR040552; DNMT3_ADD_GATA1-like.
DR InterPro; IPR049554; DNMT3_ADD_PHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR23068:SF54; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR23068; DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED; 1.
DR Pfam; PF17980; ADD_DNMT3; 1.
DR Pfam; PF21255; ADDz_Dnmt3b; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51533; ADD; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 17..119
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 927..983
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 1097..1229
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51533"
FT REGION 134..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1527 AA; 170763 MW; 7EBFF39725F47C60 CRC64;
MATYVDPDQT PDATAEKCSR FEVLDWLNKI LDIKFTRVEQ ICSGSCYCQL MDWLFPGCID
MSTVKFQAQD TPDFIHNYNL LQAGFRKTGV TKIVPVEELM NGRFQPNFVF LKWFKRFFQA
NLVGQVYNPV EARQGQEIQP ARPPLRSPQG LGRKSASRNP SQSEGLETNT DEEALGKYLR
KRIVYEDIWR ETHSWVGPST LGEFHAYCSL CDMNFNIYHS GLVDLKRHSQ CKRHHKLTLA
ANGCNVRTEA RKSSQGSISS CPPCSELVLC FIQVNCVSGP SAAGDQVSNR YGQYVLGLQY
PEDIVSTCQK TPYCIYMYGG VVLGEAGVAS VVLVGYFDVK AARHCIRLLD VLQSPAEDNT
GEETAAALVE TLKRFGLPAA NLAALYTDGN GAASEQICSQ LRELNPNVVV LGRLYGVADA
SCHAGMVELS TQAQELIVDI YSHYSFCSTK NDNLKELFSS ISSIDGLTLP LTTCCLNFCM
LARKVLEMWT DLISHFSSCN KEDDIDEKAK LISTQLQDPQ IRATFMFLNQ ALEPLRAFQE
RLHHHEGSAR ADLVQILQEA SNLLRSYASS FLRPQAVVRF LKERDVSLLK NTKFHLPGPE
LNVGGAAVED FLCESSESGS EALQFLQEQA LSFYTALTAS VAEGLPLSDG VLRSMAQLLS
PQGRLKVTRK VVGELGAKLG LCSSPEEISQ LNKEFLEYQL AEEGEWEEGE NGSDAGIQNG
FAATSLEQHW CNVLKASGST SIFRKLVLTL LALPCPPLEA QKVFTQAVQN GDAAQFTDNV
TESELDSVRE VDLTNDSALS DNNSIYEPGM KKRGRPKKIP SDGPKNEDDT VFVEDNVLWT
NSMEGTIRGI YGWESSLRQK PQARTVFQAG AGTWVKPQAL DNDSKKDQES KAASPPKKEN
HTSNVSTTSP RGAKKGIDYQ DGKGFPTGEL VWGKVKGFSW WPGLVVLWKS NKAPPVSKRR
VEWFGDGMFS EIYTERLLHL AAFAKCFCKN SYSSLPTYKD AIYQVLELAG ERCEKSFLAA
GNKQELLKLM LDWAYSGFLP TGPDGFNPPP PANAKDSKAE SSDSSLADYQ PPAKKKYLNK
NRPSYGNQSY SREAMVQEVM KGKHVKEFCL SCGTPHIHTF HPLFEGSLCL KCKENFIETL
YRYDEDGYQS YCTVCCAGQE VILCGNASCC RCFCKDCLNI LVGDGTFDKL KDVDPWSCFM
CLPSQCNGSL KLRTDWSVRV QEFFVNNSAL EFEPHRVYPS IPAHQRRPIR VLSLFDGIAT
GYLVLKDLGF IVERYIASEI CGDSIAVGMI KHEGKIEHIN DVRTITRKHL AEWGPFDLLI
GGSPCNDLAC VNPARKGLFE GTGRLFFEYY RMLTMMRPRD DDDRPFFWLF ENVVAMRGHD
LADICRFLEC NPILIDAVKV SPAHRARYFW GNLPGMNRPL ATSLDDKVNL QDCLEPGRTA
KYNKVRTITT KSNSIRQGKM GSLPVDFNGK EDYLWCTEME KIFGFPKHYT DVNNMGRSQR
QKVLGRSWSV PVIRHLFAPL KDYFACE
//
