ID A0A1S3LQW7_SALSA Unreviewed; 362 AA.
AC A0A1S3LQW7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ectodysplasin-A-like isoform X3 {ECO:0000313|RefSeq:XP_013992979.1};
GN Name=LOC106567777 {ECO:0000313|RefSeq:XP_013992979.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013992979.1};
RN [1] {ECO:0000313|RefSeq:XP_013992979.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013992979.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR RefSeq; XP_013992979.1; XM_014137504.1.
DR AlphaFoldDB; A0A1S3LQW7; -.
DR GeneID; 106567777; -.
DR OrthoDB; 5361136at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..275
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 102..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..205
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 39861 MW; ABE51B2AB24D48BD CRC64;
MAPKSLSEKL ANLEDSDLKE STCSCRKQCK NCKIFLGFFV LSLSLHLVTL FCYLDLRSEV
KREILQKNRE ETVSPAATDM NDRYSPVFQL LDISYPADIQ NRLPLGNSDE NSHLKEDRDN
AVHRTKRSQQ NKRLDSESHG NKRKERKKGK KGPPGAPGPL GPPGPQGPPG IPGIPGIPGN
NAMGPSGPPG PPGPAGPPGP QGPPGLQGPS GGRVRDSQPA VVHLQGQETT IQVKEEGVLR
NWKMISMHHK VFKMHSRSGE LEVLVDGTYF IYSQVEVYYL NFTDIASYEV MVDKTPFLRC
TRSIETGQRK FNTCYTAGVC LLRARQKISI KMVYEDTSIS MTNHTTFLGS IRLGDAPPAS
HS
//
