ID A0A1S3LQX4_SALSA Unreviewed; 864 AA.
AC A0A1S3LQX4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Active breakpoint cluster region-related protein-like isoform X4 {ECO:0000313|RefSeq:XP_013993383.1};
GN Name=LOC106567975 {ECO:0000313|RefSeq:XP_013993383.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013993383.1};
RN [1] {ECO:0000313|RefSeq:XP_013993383.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013993383.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013993383.1; XM_014137908.1.
DR AlphaFoldDB; A0A1S3LQX4; -.
DR GeneID; 106567975; -.
DR CTD; 29; -.
DR OrthoDB; 2916231at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR Bgee; ENSSSAG00000048882; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF5; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 89..282
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 299..458
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 483..612
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 646..840
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 375..413
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 864 AA; 98547 MW; D95DC08E7DF68402 CRC64;
MEPLSTRGLP RLSWIDTLYS NFNYNTDGYD GDAAEDRKSQ DGSETMPFID ESPTISPSLC
ACGPDGEAIS PVPPEDLLPG GDIEKGLEMK KLVLSGFLAS EEIYINQLEA LLLPMRPLKA
TATTSQPVLT IQQVETIFYK IQDIFEIHKE FYDALFPHIQ QWDEKVAVGH LFQKLASQLG
VYKAFVDNYK TAMETAEKCS QANTQFQQIS ESLKVKGPKD SKDCNTNVTM EALLYKPIDR
VTRSTLVLHD LLKHTPKDHP DFPLLQDALR ISQNFLSSIN EEIDPRRTAV TTPKGEARQL
VKDGFLVEVS EGSRKLRHVF LFTDLLLCAK MKKTSVGRHQ QYECKWYIPL ADLTFQLLDD
SDVLPHIQVL PEHEIEEMKT KISVIKSEIQ KEKKALKGQS RNVERLRKKM NEQESWLLLH
SPTIPFRIHN KHGKSYLFLL SSDYERSEWR ESIQKLQRKD LQTCQLSSVE LQVLTSSCFK
LRTVHNIPVT SNKDDEETPG LYGFLHVIVH SAKGFKESAN LYCTLEVDSY GYFVSKAKTR
VFRDTTEPQW NEEFEIELEG SQCLRILCYE KCYDKTKLNK DDNEIVDIIM GKGQVQLDPQ
TVQSKNWHMD VIEMNGIKVE FSMKFTSRDL SLKRTPSKKQ SGVFGVKISV VTKRERSKVP
YIVRQCIEEV EKRGIDEVGI YRISGVATDI QALKAAFDTN SKDILVMLSD MDINAIAGTL
KLYFRELPEP LLTDRLYPAF MEGIALSDPA AKENCMMHLL RSLPDPNLIT FLSLLEHLKR
VADNEPINKM SLHNLGTVFG PTLLRPSESE VTKGHITLAT DIWSHDVMAQ VSVTWVQVLL
YYLQHPPISF AELKRNTLYF STDV
//