ID A0A1S3LU10_SALSA Unreviewed; 894 AA.
AC A0A1S3LU10;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Semaphorin-4D isoform X2 {ECO:0000313|RefSeq:XP_013994351.1};
GN Name=sema4d {ECO:0000313|RefSeq:XP_013994351.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013994351.1};
RN [1] {ECO:0000313|RefSeq:XP_013994351.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013994351.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_013994351.1; XM_014138876.1.
DR AlphaFoldDB; A0A1S3LU10; -.
DR Ensembl; ENSSSAT00000238788; ENSSSAP00000168142; ENSSSAG00000053620.
DR GeneID; 106568487; -.
DR CTD; 10507; -.
DR OrthoDB; 5342713at2759; -.
DR Proteomes; UP000087266; Chromosome ssa13.
DR Bgee; ENSSSAG00000053620; Expressed in muscle tissue and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..894
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010270105"
FT TRANSMEM 760..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..497
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 555..624
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 651..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 99124 MW; FA1363914B1E3716 CRC64;
MVFGVLGVFL GLLLEVSTHG PHSIPRTSWK HEELKLVEFS EPGIFNYSTL LLSEDKDVLY
VGAREAIFEL RMTNVSIKNN KVQWKVPENH MTMCIVKGKS KETDCLNYIR VLQVLDDKRL
YVCGTHAFQP VCHYLSLKDF SLEGPAEDGR GKCSFDPSQS FTTVMVDGEL YSGTSYNFLG
SEPIISRYSL SQSLLRTEYS TSWLNEPSFV FADVIREGKN SADGEDDKIY YFFTEVSVEY
EFFGKLLIPR IARVCKGDLG GQRTLQKKWT SFLKAKLVCS MPELNFVFNV VNDVFILKTA
DWRETVIYGV FTSQWGNVGL SAVCAYDMLS VENVFSKGKY MQKATVEQSH TKWVRYNGIT
PSPRPGACIN NHHRLQNISS SLHLPDKTLQ FVKDHPLLED PVLPIGNGPK LITKDVSYTQ
IVVERVQALD NNVYDVIFTG TDKGILHKSV VYDGLVHTVE EIQLLPKSEP IKTLLLSSQG
TRSLYAGSDS GVVQSPTAFC DKYPSCSDCI LTRDPYCAWD PDSSTCVNIF HTQGLTHRNL
IQSLNGDADK CPSAPGLSVE NYQRVTVKPG SSAELPCLVQ SNLAVVIWKQ NSSTMTEASK
FHLMGETGLL IYSVAPEDHG LYECWSLEWA PVAGKNFSRL LAGYVLDLDG PRRPSPRGHP
PQTASTLSSA HPHHQSTAAT EGNNGNTVRP LPLTSAPPNS TALTSPPPTH SASSSLTKPP
SSSTARLQPK LLPPSSSAVP LPETRDPATE YLQHDNSSTF LFLFLLFFLL FLAALVYNCY
MQYLPGPCLR LRAALLGSQK KPQPEYLACE AGLMEPVTVD KLDVKDQIRL TQNGVQLRAL
RDTGYETEPE CSNGKIPSRS YGGEDSPSKE KPFDVDCDSQ PIEYADADQE ASPY
//
