ID A0A1S3LW81_SALSA Unreviewed; 1695 AA.
AC A0A1S3LW81;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN Name=LOC106568870 {ECO:0000313|RefSeq:XP_013995100.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013995100.1};
RN [1] {ECO:0000313|RefSeq:XP_013995100.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013995100.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
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DR RefSeq; XP_013995100.1; XM_014139625.1.
DR STRING; 8030.ENSSSAP00000105643; -.
DR PaxDb; 8030-ENSSSAP00000105643; -.
DR GeneID; 106568870; -.
DR OMA; VASWPWF; -.
DR OrthoDB; 167745at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR Bgee; ENSSSAG00000074868; Expressed in sexually immature organism and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..227
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 274..595
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 652..834
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 842..1067
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1095..1164
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1183..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1621..1695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1695 AA; 190956 MW; F53E09F2B41393A2 CRC64;
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDED VHFRISEEKI
FADIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKALEKGE
VLPSEARFDS NCITPGTDFM ARLQEQLKYF VNSKLSTDNA WKGVNVYLSG HETPGEGEHK
IMEFIRRENS EPGHDPNTRH CLYGLDADLM MLGLTSHEPH FSLLREEVRF GGKKNQKRIT
APEETTFHLL HLSLFREYID YEFSEVKNKI SFEYDLERII DDWILMGFLV GNDFIPHLPH
LHINQDALPL LYRTYISVLP TLGGYLNENG HLNLGNFEKY LEKLSEFDRE HFNEVFVDLK
WFESKVGNKY LNEAAGLAAE EAHSKDARKK DLDSLRLTTL DDGKDRAPGR GFEEDGEEED
MFEAEFRQYK RTYYMTKMGV EVVSEEFLAN QALCYVEGIQ WILHYYYHGV QSWSWYYPHH
YAPFLSDVRN IAHLKLTFDM GKPFMPFQQL LGVLPAASKD LLPESYRHLM TSENSSIIEY
YPLDFKTDLN GKQQEWEAVV LIPFIDERCL LAAMEPYNDH MTKAEKARNR HTECAVYSYD
AELDYPYTST LPDLFPNIMH CHVRVTPIPM DAWHVSLSHV GRSDNSSQLY FLGFPTLQHI
RHKFYKKKHG VVVFQQSSRG ENMMLEITRS KEEPVCGDVA ALVLGCSVFV NWPHLEEARV
VAVSDGESKF SLEELAGVQK LYDRDSPPPT KVTYLSDKEQ KDWVKDVQGI TEHFSKRKGI
VVNVTAVVLY AQLLTGRKYV PGQSGQVHLE KQWSKQIMPF AYQTIVKDIK AFDSSSTRFQ
TLEELFPPTT TVFMVGNPYY GTMGEVQESS DVIKEGRVWV VFTVPCEPPM EALIQNQHKY
CVKYSPGYVL ASRLGITSYL VSRFSGSIFV GRGSKKNPHG EQKANVGLNL KFNKKNEEVP
GYTKRTEKEW LYSDAVEELM SEYLDRFSEV FDLVSRNSHD DVFYEDDIWP AEYQNGAEKV
KEITSWLKTH PVADVARASC DLQILDKAIV ERIEEEVVKA KVKKSNEKVR VTVKPHLLFR
PLEQQHGVVP DPDAEYHLFD RVVNVRESFS VPLGLRGTVI GIKAADREAE VLYEVVFDEE
FAGGLTIRCA AGRGYRLPPC ALINLSHGGR VEQGFHKLTA VVKPQPASSH QHNKGQMVGL
NHSPRSPFIS TQQQNGRQNI LRADTQGNKN SAHKASQKPK PKGKDEEFSN VWQSLQSSGM
PQKPPAHWQQ DNSGKSAWGT GSPGKEGQFQ GQQGRNQPQS QQPQPPKPGP TGSIRLLKRN
EDVNSLFPAQ NATKKQTEFE ELIANLKISK GNESTPPPPA KEPTSQTEEP LSPQSFAMKG
TLALKEMLNI GAAPDSTSPV SFNTQQQNKR RPTKKLAARM GDSVLPAAPA VAVPPLQSPQ
PSSIIPSVAS ELTRICMGLG MAPPDFTFMR SRQGLLVYQV KLSSGLVVQG PQCQSENEAK
EKAALFALQR LNSVGSGFPL PPPMFSGVGQ IRGPPMGPVP NIFGQSGGLL MPPQGYGPLH
WGMPLPPHQG QPFYGGTFPG ARPQAPSVPI GSHNQFVPLQ VTKKRVSSVE KPQEFCNAAH
KARNQAPGSE FPSHSQPSLS PAPSTPPKTA QAAGTPSTPQ TPRQNPSGQG HTPGSASKRK
HRKLAVNFEA AKVQE
//
