ID A0A1S3LXA9_SALSA Unreviewed; 1194 AA.
AC A0A1S3LXA9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Ras GTPase-activating protein nGAP-like isoform X7 {ECO:0000313|RefSeq:XP_013995495.1};
GN Name=LOC106569068 {ECO:0000313|RefSeq:XP_013995495.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013995495.1};
RN [1] {ECO:0000313|RefSeq:XP_013995495.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013995495.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013995495.1; XM_014140020.1.
DR AlphaFoldDB; A0A1S3LXA9; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 128..162
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 153..271
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 331..523
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1033..1106
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1194 AA; 133855 MW; 160538A705CB2EE8 CRC64;
MMGNSCDRVS GERSPRRRSI SGLGNSEKNI SLDVPNSSPF KVPGFFSKRL KGSIKRTKSQ
TKLDRNTSFR LPSLRPSEND RSRGLPKLKE SCSHESLLSP GSAVEALDLG MEEDVYVKPL
HSSILGQEFC FEVTYSGGSK CFSCSSASER DKWMENLRRT VQPNKDNCRR TENVLRLWII
EAKDLPPKKK YFCELCLDDI LYARTTSKTR ADCLFWGEHF EFYSLPSVRS ITVHIYKDVD
RKKKKDKNNY VGLVNIPIGG VTGRQFVEKW YPVSTPTTSK GKGGGPSIRI KSRFQTISIL
PMEQYKEFAE FITNNYTMLC SVLEPVISVK NKEEMACALV HILQSTGRAK DFLTDLVMSE
VDRCADHDVL IFRENTLATK AIEEYLKLVG QKYLHDALGE FIKALYESDE NCEVDPGKCS
SSELPEHRSN LKMCCELAFC KIINSYCVFP RELKEVFAAW KQQCLTRGNQ DISKRLISAS
LFLRFLCPAI MSPSLFSLMQ EYPDDRTSRT LTLIAKVIQN LANFAKFGNK EEYMAFMNDF
LEHEWAGMMR FLTEISNPET ISNTPGFEGY IDLGRELSVL HSLLWDVVSQ LDKGENSFLQ
ATVAKLGPLP RILGDIARSL SSPTPIQQQL RRFQDYSSSH NISGSISSGL QRIFEDPADS
EVGRNKSPVQ EHVTNGLHRG KHPLLGQQSS GHSMSFSDKD ERENLLPSGR SISLVDLQDS
HMVQSGKGPL PLHDAPPKLS RVGSQLSIGH PHQATTSQSH QALHQKPSLQ DNLPQSAPQV
RRPLHPSLSQ QRSLQPLSFQ NPVYHLSNQT QQQTAVHSTT HSVHSHSVHS LQPDSSSENL
STDSSRSHSN SEVEFGGGSQ GGKGGRVPSN SSLEEFSRRS TQSEDCSTPR RHNLPDHHRG
AHAVAVPRQS STAHIVRVEQ QSRSGGSGGA RTPRSLPRSL PHSASLRSSS SINTEPMPIP
IQAQPGTGGR SHQQSTCSME SPVPAVRSVA KQQTPPQVAS PVEPVTMSPV ERTAAWVLNN
GQFEDEAAPA DQSREDSRHA KKYEQEISKL KERLRVSSRC LEEYERRLLA QEQQMQKLLM
EYKARLEDSE ERLRRQQEEK DNQMKSIICR LIAVEEELKR DHAEMQAVID AKQKIIDAQE
KRISSLDAAN SRLMSALTQV KERYSMQNLH NGLSPTNPTK LSITENGEFK NSNC
//
