ID A0A1S3LZ34_SALSA Unreviewed; 699 AA.
AC A0A1S3LZ34;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN Name=LOC106569378 {ECO:0000313|RefSeq:XP_013996167.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013996167.1};
RN [1] {ECO:0000313|RefSeq:XP_013996167.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013996167.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR RefSeq; XP_013996167.1; XM_014140692.1.
DR AlphaFoldDB; A0A1S3LZ34; -.
DR STRING; 8030.ENSSSAP00000011012; -.
DR PaxDb; 8030-ENSSSAP00000011012; -.
DR GeneID; 106569378; -.
DR KEGG; sasa:106569378; -.
DR OrthoDB; 1330770at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..699
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010317360"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..210
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 699 AA; 77764 MW; E672CCB5BF39B343 CRC64;
MALESSKWVM FIVCWLFKNV SCNSVAQKIY VELNNTVPCV RLLNATHQIG CQSSISGDTG
VIHVLESEAD LEWPLSKGPN PPYMVLLESS LFTKSIMMKI KNASSRVAGV VVVPKTSPPE
FSPHTTCPNE NTGVYTETYD HHLAHCNTTV WNPRGNGLSY EEFDFPVFSL KEDNETEAIK
QCYFDHNRVV NGSGLQYPLC AMQLLSHMYA VTDTATCMRR RSIDFSTSPV MVCNPLGDYN
VCAFIRPYNS TAFGHKENES VVVAAARLDS RAFFLQDSTG AEGSVSGFVT LLAAAQALRE
ATQEAPPTRN ILFAFFHGEV FDYIGSSRMV YDMKNNKFVI DLDNVHSILE IGQVAVRSGT
NLFLHSDPVS RRNNTVHDEV TNLVKNLQSS TAGLNFSFVE TGFSQPLPPS SFQRFLRARA
IPGIFLADHQ TAFNNRYYES FYDNAAHLNL TYPSNLSPEE QLEFVTDTAK SLTEVATAVA
RALFKQAGGN NSLVNNINAD PKTVTQMLYG FLVRSNNSWF QALMAPELKD VLQPNPPQYY
VGVAKLPHQA NALTYLVQYL LANLTGTATN LTQSQCKKPD ELPNESTYMY SYFWVQGMVL
PNSTQRESFC VRTAVRLAKA VSPAFDLGDY VSKEYSTWTE SQWTFIKARI FLVASRDLEM
LTLGVGVAVL LTSLLVTYFV STKADVLFSA VREPNNGAY
//