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Database: UniProt
Entry: A0A1S3LZ34_SALSA
LinkDB: A0A1S3LZ34_SALSA
Original site: A0A1S3LZ34_SALSA 
ID   A0A1S3LZ34_SALSA        Unreviewed;       699 AA.
AC   A0A1S3LZ34;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   Name=LOC106569378 {ECO:0000313|RefSeq:XP_013996167.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013996167.1};
RN   [1] {ECO:0000313|RefSeq:XP_013996167.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013996167.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
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DR   RefSeq; XP_013996167.1; XM_014140692.1.
DR   AlphaFoldDB; A0A1S3LZ34; -.
DR   STRING; 8030.ENSSSAP00000011012; -.
DR   PaxDb; 8030-ENSSSAP00000011012; -.
DR   GeneID; 106569378; -.
DR   KEGG; sasa:106569378; -.
DR   OrthoDB; 1330770at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa14.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..699
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010317360"
FT   TRANSMEM        660..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          38..210
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   699 AA;  77764 MW;  E672CCB5BF39B343 CRC64;
     MALESSKWVM FIVCWLFKNV SCNSVAQKIY VELNNTVPCV RLLNATHQIG CQSSISGDTG
     VIHVLESEAD LEWPLSKGPN PPYMVLLESS LFTKSIMMKI KNASSRVAGV VVVPKTSPPE
     FSPHTTCPNE NTGVYTETYD HHLAHCNTTV WNPRGNGLSY EEFDFPVFSL KEDNETEAIK
     QCYFDHNRVV NGSGLQYPLC AMQLLSHMYA VTDTATCMRR RSIDFSTSPV MVCNPLGDYN
     VCAFIRPYNS TAFGHKENES VVVAAARLDS RAFFLQDSTG AEGSVSGFVT LLAAAQALRE
     ATQEAPPTRN ILFAFFHGEV FDYIGSSRMV YDMKNNKFVI DLDNVHSILE IGQVAVRSGT
     NLFLHSDPVS RRNNTVHDEV TNLVKNLQSS TAGLNFSFVE TGFSQPLPPS SFQRFLRARA
     IPGIFLADHQ TAFNNRYYES FYDNAAHLNL TYPSNLSPEE QLEFVTDTAK SLTEVATAVA
     RALFKQAGGN NSLVNNINAD PKTVTQMLYG FLVRSNNSWF QALMAPELKD VLQPNPPQYY
     VGVAKLPHQA NALTYLVQYL LANLTGTATN LTQSQCKKPD ELPNESTYMY SYFWVQGMVL
     PNSTQRESFC VRTAVRLAKA VSPAFDLGDY VSKEYSTWTE SQWTFIKARI FLVASRDLEM
     LTLGVGVAVL LTSLLVTYFV STKADVLFSA VREPNNGAY
//
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