ID A0A1S3LZR0_SALSA Unreviewed; 1959 AA.
AC A0A1S3LZR0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106569513 {ECO:0000313|RefSeq:XP_013996417.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013996417.1};
RN [1] {ECO:0000313|RefSeq:XP_013996417.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013996417.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_013996417.1; XM_014140942.1.
DR STRING; 8030.ENSSSAP00000114609; -.
DR PaxDb; 8030-ENSSSAP00000114609; -.
DR GeneID; 106569513; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR Bgee; ENSSSAG00000065535; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013996417.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..45
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 46..1959
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010219144"
FT TRANSMEM 1304..1328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 151..234
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..334
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 341..431
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 436..530
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 534..624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 629..731
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 736..844
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 845..952
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 953..1056
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1060..1144
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1400..1659
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1579..1650
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1691..1950
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1868..1941
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 417..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1959 AA; 218152 MW; AF9E47950A2F6A48 CRC64;
MVPPKPGGTV AQSRATRPGY GLCFYHPCLL LPLLVLTSLP NVSEAVAAPK FTKIPGDQIG
VSGGVASFVC QASGDPKPMV NWNKKGKKVN SQRIETIEFD DGAGAVLRIQ PLRAPRDENV
YECVARNSEG DVATTAKLAI IREDLLPFGF PSIDMGPQLK VVERTRTATM LCAASGIPDP
EISWFKDFLP VEPSSSQGRI KQLRSGALQI ENSEELDQGK YECVATNSQG VRYSSPANLY
VREQREVRRV PPRFSILPSN HEIMPSGSIN ITCVAVGSPM PYVKWMLGSE DLTPEDEMPV
GRNVLELNGI RESANYTCVA MSSLGIIEAT AQVSVKTLPK PPGTPIVTET TATSVTITWD
SGNPDPVSYY IIQYRAKAPD SKYETVDSIT TTRYSIGGLY PNTEYEIRVS AFNSIGQGPS
STRVEARTGE QAPASPPRNV QARIISKNTV MVRWEEPEEP NGQVKGYRVY YTMDPSQPMS
LWQIHNVQDS TITSIQSLVP SETYTVRVLA FTSVGDGPFS DPVHVKVLPG VPGQPGKFKV
GKVTETSIEL TWEPSYIKEG IVNYELLYKP VKFGSLEKLT FGPRASYTVE GLRANTEYSF
SLAAISNKGI GAFTNELVQR TAQAKPSAAP LGVSCDSPSS TSLRVSWTPP PTETQNGTLT
AYVLRYQQVV SGAEVKGQGP EVKGPPIPPE QGQAVVEGLE KWTWYRVSLA AFTTEGSGPE
SPALLCRTDH DVPGAAPRQV EVRPFNSTAL RVTWRSVLPR QRQGQIRGYQ VHYARVESGS
SRILPRIKDL LLDDSQFVED DSTEYEMIVG GLKPEMWYSV SVAAYTTKGD GTHSKAKVVQ
TPGIVPGAPS LSVRPGSEPS MVVRWGPPTG GSDSGPGAKG SEVQIQGFRL QFGLKNATLD
TTVEFSARER TYTLTDVIPG LTYVVTLSAK SRSGYGDEAR EELKMPEYPP RGYPQISEYI
NATCCSLQFS WLPPVPSERN GVITEYTIAY REAGGLNPLG IDPLGPPRQI TLPAIVSSYT
ILGLNHNTGY EVQMCAHTSV GPGPFSPPLL YRTLAFETDV PRNFSVNLAT KTSVLLTWEF
PESPYPYHFT VEYNRQKMEV DAKLRKAVIP NLQPDTDYDF KITSSEGNMG GLRHRIHAKT
SPPIAIRRPE IDHTRDTETT ITIILPSLEN RIPVKNLYVV VVPLRRARGV IRHLKSPDEM
DLEELLKDSS QRQRESRQQK QVDLRRAYIS ALFTPATLPA FFTLGDQLDY GGFENRALEP
GQEYVFFILA ELNGTTVKMY ADSPYTEPVI APDSDPQPLD AGDGLIWVVG PVLAVVFIIC
IVIAILLYKN NKPDSKRKDS EPGTKSLLCN AEMMAHHPTD PVEMRRINFQ TPGMMSHPPI
PITELAEHTE MLKANDSLRL SQEYESIDPG QQFTWEHSNL EVNKPKNRYA NVIAYDHTRV
VLAPIEGSSP GILGSDYINA NYIDGYRKQN AYIATQGPLA ETFGDFWRMV WEQRAASVVM
MTRLEEKSRI KCDQYWPTRG TETYGMTQVT ILDTMELATF CVRTFSLQKN GCNERREVRQ
FQFTAWPDHG VPEYPTPFLA FLRRVKACNP PDAGPVIAHC SAGVGRTGCF IVIDGMLERI
RHERTTDIYG HVTLMRSQRN YMVQTEDQYG FIHEALLEAV ACGNTEVAAR SLFSYMQKLG
KVESGEHVTG MELEFKRLAN TKAHTSRFVS ANLPCNKFKN RLVNIMPYET TRICLQPIRG
LEGSDYINAS YIDGYRQQRG YMATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK
CHQYWPAERS ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTVRQF QFTDWPEQGV
PKSGEGFIDF IGQVHKTKEQ FGQDGPISVH CSAGVGRTGV FITLSIVLER MRYEGAVDIF
QTVKMLRTQR PAMVQTEDEY QFCYQAALEY LGSFDHYAT
//
