ID A0A1S3M007_SALSA Unreviewed; 847 AA.
AC A0A1S3M007;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 isoform X5 {ECO:0000313|RefSeq:XP_013996381.1, ECO:0000313|RefSeq:XP_013996382.1};
GN Name=rapgef4 {ECO:0000313|RefSeq:XP_013996381.1,
GN ECO:0000313|RefSeq:XP_013996382.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013996381.1};
RN [1] {ECO:0000313|RefSeq:XP_013996381.1, ECO:0000313|RefSeq:XP_013996382.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013996381.1,
RC ECO:0000313|RefSeq:XP_013996382.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013996381.1; XM_014140906.1.
DR RefSeq; XP_013996382.1; XM_014140907.1.
DR GeneID; 106569502; -.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 60..135
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 200..301
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 333..466
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 608..845
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 96704 MW; 805A385235254EA6 CRC64;
MAGLLAPPYG AMETGSNNDR LTDKDSLGSD PLNFMNKILN KVPSEKLQRG GKVMRNAILS
RAPHMIRDRK YHLKTYRQCC VGTELVDWLV QQSTCVHTRS HAVGMWQVLL EEGVLNHVDQ
ELGFQDKYLF YRFLDDEEEH TPLPSEEEKR ESEEELPETI LFLAQMGPDA LLRMILRKPP
GQRTGEDLEI IYDELLHIKA LSHLSNTVKR ELAGVLIFES HAKAGTVLFN QGEEGTSWYI
IQKGSVNVVI YGKGVVCTLH EGDDFGKLAL VTDSPRAASI VLREDNCHFL RVDKEDFNRI
LRDVEANTVR LKEHEQAVLV LEKSPRASSL GNIRYTVLSG TPEKILDHFL ETMRMDTHHS
DPDPGVDDFV LMHCVFMPNS QFCQLLMAHY HAVAPPGSEQ ERLEYAVTCK RRVLNLALRW
AAVHTHHLQE EPAALIFLEE LYGSVSSVSN DSRILRALKD FVPDLEKVVK LHSEEAKVKK
QKVLTQFSNG DEKLVKTQPI RNCDDILLKV YCSDHTYTTI RVAVAATGSE VTSAVAYKLA
SNDDLLLVHL SSAGEKQMLK PNDVSVFSSL SINGRMFACP RDQLNALTPL PDQEGPSAGS
MSSFELMSSK DMAYQMTLYD WELFSCVHEH ELLYHTFGRQ RFRRTTANLD LFLRRFNQVQ
LWVVTEVCLC GQLSKRVQLL KKFIKIAAHC REFKNLNSFF AIIMGMSNPA VSRLTQTWEK
LPSKFKKFYA EFESMMDPSR NHRAYRLTVT KIEPPIIPFM PLLLKDMTFS HEGNKTFIDN
MVNFEKMRVI ANTIRAVRHC RSQPFNPEVC QPNKNHAEVR GYVRKLCVID KQRTLTTLSY
RLEPCRT
//
