ID A0A1S3M0E6_SALSA Unreviewed; 1529 AA.
AC A0A1S3M0E6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106569513 {ECO:0000313|RefSeq:XP_013996409.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013996409.1};
RN [1] {ECO:0000313|RefSeq:XP_013996409.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013996409.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_013996409.1; XM_014140934.1.
DR GeneID; 106569513; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013996409.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..45
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 46..1529
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010310156"
FT TRANSMEM 870..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 151..234
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..334
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 341..431
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 436..530
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 534..624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 626..710
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 970..1229
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1149..1220
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1261..1520
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1438..1511
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 417..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1529 AA; 171643 MW; 6765A5CADF9FBD4E CRC64;
MVPPKPGGTV AQSRATRPGY GLCFYHPCLL LPLLVLTSLP NVSEAVAAPK FTKIPGDQIG
VSGGVASFVC QASGDPKPMV NWNKKGKKVN SQRIETIEFD DGAGAVLRIQ PLRAPRDENV
YECVARNSEG DVATTAKLAI IREDLLPFGF PSIDMGPQLK VVERTRTATM LCAASGIPDP
EISWFKDFLP VEPSSSQGRI KQLRSGALQI ENSEELDQGK YECVATNSQG VRYSSPANLY
VREQREVRRV PPRFSILPSN HEIMPSGSIN ITCVAVGSPM PYVKWMLGSE DLTPEDEMPV
GRNVLELNGI RESANYTCVA MSSLGIIEAT AQVSVKTLPK PPGTPIVTET TATSVTITWD
SGNPDPVSYY IIQYRAKAPD SKYETVDSIT TTRYSIGGLY PNTEYEIRVS AFNSIGQGPS
STRVEARTGE QAPASPPRNV QARIISKNTV MVRWEEPEEP NGQVKGYRVY YTMDPSQPMS
LWQIHNVQDS TITSIQSLVP SETYTVRVLA FTSVGDGPFS DPVHVKVLPG VPGQPGKFKV
GKVTETSIEL TWEPSYIKEG IVNYELLYKP VKFGSLEKLT FGPRASYTVE GLRANTEYSF
SLAAISNKGI GAFTNELVQR TAQANVPRNF SVNLATKTSV LLTWEFPESP YPYHFTVEYN
RQKMEVDAKL RKAVIPNLQP DTDYDFKITS SEGNMGGLRH RIHAKTSPPI AIRRPEIDHT
RDTETTITII LPSLENRIPV KNLYVVVVPL RRARGVIRHL KSPDEMDLEE LLKDSSQRQR
ESRQQKQVDL RRAYISALFT PATLPAFFTL GDQLDYGGFE NRALEPGQEY VFFILAELNG
TTVKMYADSP YTEPVIAPDS DPQPLDAGDG LIWVVGPVLA VVFIICIVIA ILLYKNNKPD
RSLSSKRKDS EPGTKSLLCN AEMMAHHPTD PVEMRRINFQ TPGMMSHPPI PITELAEHTE
MLKANDSLRL SQEYESIDPG QQFTWEHSNL EVNKPKNRYA NVIAYDHTRV VLAPIEGSSP
GILGSDYINA NYIDGYRKQN AYIATQGPLA ETFGDFWRMV WEQRAASVVM MTRLEEKSRI
KCDQYWPTRG TETYGMTQVT ILDTMELATF CVRTFSLQKN GCNERREVRQ FQFTAWPDHG
VPEYPTPFLA FLRRVKACNP PDAGPVIAHC SAGVGRTGCF IVIDGMLERI RHERTTDIYG
HVTLMRSQRN YMVQTEDQYG FIHEALLEAV ACGNTEVAAR SLFSYMQKLG KVESGEHVTG
MELEFKRLAN TKAHTSRFVS ANLPCNKFKN RLVNIMPYET TRICLQPIRG LEGSDYINAS
YIDGYRQQRG YMATQGPLAE TTEDFWRMLW EHNSTIVVML TKLREMGREK CHQYWPAERS
ARYQYFVVDP MAEYNMPQYI LREFKVTDAR DGQSRTVRQF QFTDWPEQGV PKSGEGFIDF
IGQVHKTKEQ FGQDGPISVH CSAGVGRTGV FITLSIVLER MRYEGAVDIF QTVKMLRTQR
PAMVQTEDEY QFCYQAALEY LGSFDHYAT
//
