ID A0A1S3M0X5_SALSA Unreviewed; 1039 AA.
AC A0A1S3M0X5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 3-like isoform X2 {ECO:0000313|RefSeq:XP_013996563.1, ECO:0000313|RefSeq:XP_013996564.1};
GN Name=LOC106569585 {ECO:0000313|RefSeq:XP_013996563.1,
GN ECO:0000313|RefSeq:XP_013996564.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013996564.1};
RN [1] {ECO:0000313|RefSeq:XP_013996563.1, ECO:0000313|RefSeq:XP_013996564.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013996563.1,
RC ECO:0000313|RefSeq:XP_013996564.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_013996563.1; XM_014141088.1.
DR RefSeq; XP_013996564.1; XM_014141089.1.
DR STRING; 8030.ENSSSAP00000030422; -.
DR PaxDb; 8030-ENSSSAP00000030422; -.
DR GeneID; 106569585; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR Bgee; ENSSSAG00000039702; Expressed in nose and 11 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR SMART; SM01288; FISNA; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..96
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 197..332
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1039 AA; 119376 MW; F957025EE7A778A5 CRC64;
MNKMESSEHS AQFVDKYMPQ LIQRVTMVMP IADKLLAEGM IHEEVYSNIS AARTNQGKMR
ELFIALHSGG NKVKSTFLSI LRENNPDLVQ DLECHGKQRV EQEDKSTTSL KYKEFIRGEY
ATVQEYNSLP GEHVKLDDRY TEPLIIQKHR LQREREEEIR SRGQNFYLLM DQRDSETYKS
TKVERLFDPD EHGDIQRTVI LQGHSGTGKS FTTQKIMSDW AFGRLYKDRF DFVFHLRCKE
LNQATGRKSL MDLLNYNQSS SSMIKQVLCQ SPERVLFLVD GFDELKFSLD VPKDTLPRDP
WTQCSPEVTL SGLIRKQILH ESFLLVATRS TALDKLNRVV KNPVRCAEIL GFSKEGVEEY
FQRFFKKEQH SQQAYDSVRK NETLFTACFI PVICWIICTV YREQFYEGTE MIQSLETTTS
IFVEFVATLL KHHCQDLGQS DLTILQGLGK LAEKGTEEQQ VLFDHHSVSQ TVSDPSKVPF
LCKLLQKKRV SQTTMYSFMH LSFQEFFTAL SYMLLGDEEA QGKVRELLSK VRRGKENSHL
LPIVQFLFGI ANKEVGKRLE DKKYISCSQG IWTQLKHFIL EVIEKEKEDR NAIDYHISSM
WLFAFHCLYE LHVDDFVKKA MNTYTEFNLT HITLTKTDCW VLKYCFQHCK CIERLILNLC
KLTADKIKIL LPALEKCQHL ELQVDGLADD DLDDLLTALG EGKSLELDLS ENNFSDEKVQ
DLLVALTKHK PRNVDIGVKS ITSNTADKFM FLISKSHGVL ESIGLYGCKN VTLEANLQKN
GVNGTLQTFL WLKVSDMKMI CDCIRASGYS LSEIVLSVNY VVNLSDTDVD DLSAIIHPVD
KLRLSFQHQH LYGQDAVSEG LQSQISLRRI EITLYGNPVF DWRKVFQLVH TLGQHPEWDE
HVEGLISLLH SQTSLVGIDL YVSSLTERCA ASVVSLSQAC PNLRMISLHV VEHGLLLEEV
LQRLRVSKRH PDCRLLVAGW RCRKPADKCT GRKDWSLCCD DSVRLTLHGE TFTENVIRHG
KESDRPSDHP KSNRWCVVA
//