ID A0A1S3M2A1_SALSA Unreviewed; 881 AA.
AC A0A1S3M2A1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Zinc fingers and homeoboxes protein 1 {ECO:0000256|ARBA:ARBA00040117};
GN Name=LOC106569931 {ECO:0000313|RefSeq:XP_013997166.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013997166.1};
RN [1] {ECO:0000313|RefSeq:XP_013997166.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013997166.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR RefSeq; XP_013997166.1; XM_014141691.1.
DR AlphaFoldDB; A0A1S3M2A1; -.
DR STRING; 8030.ENSSSAP00000056105; -.
DR PaxDb; 8030-ENSSSAP00000056105; -.
DR Ensembl; ENSSSAT00000084865; ENSSSAP00000055299; ENSSSAG00000049929.
DR Ensembl; ENSSSAT00000248853; ENSSSAP00000127889; ENSSSAG00000049929.
DR GeneID; 106569931; -.
DR KEGG; sasa:106569931; -.
DR OMA; GKRINNW; -.
DR OrthoDB; 5350395at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR Bgee; ENSSSAG00000053956; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 5.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF4; ZINC FINGERS AND HOMEOBOXES PROTEIN 1; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR Pfam; PF11569; Homez; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 5.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 5.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 305..348
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 450..510
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 578..628
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 651..711
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 307..349
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 452..511
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 580..629
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 653..712
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..864
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 99133 MW; 0A95B4A253EFF6FC CRC64;
MASRRKTTTP CMFPPIEMVN SDPDMEVVTE GDEQTDEGAA NCPVENSTES NPSEEDTQAM
DHFIKTMDSS TAEGGYECKY CSFQTSQLNM FTLHVDTEHP NIVLNSSYVC VECDFHTKRY
DALLEHNARH HPGEDSFTRT MVKSNNQTIF EQRVNDLTFD GSFVEEDEDT SCKGIALSKT
PIMKLKSRAE AKKFTGSHKM ADYSVIKVES DGEEETEEMP PPPLTPTVVA VSTPLTIQPI
QQSIMVNSPN VLQIKTTNST TMLPPGTLAQ VLSALQNQQT SQTQLLIPVS SIPTYNGAMD
NNVLLVSAYN RFPYPSVSEI MGLAAQTKFT EEQIKVWFSA QRLKHGVSWT PEEVEEARRK
KFNGSVQAVP QTITVIPANF ATAANGLQSI FQTCQIVGQP GMVLTHVGGG NAVPVASPIT
LAVAGVPNPR TSVSKVPEPS TSETASPLST DSLGARPKKS KEQLAELKAS YLRRQFATEA
EISRLMKVTN LTKRAIKKWF SDTRYNQRNS KDHQGLALND ISVNTNSNDG SSSTAIVIDS
SDEASESSLT TQGPIYDPRI KFRHAFPDFT PQKFKEKTPE QLLLLEASYQ KSDTPGDEEL
SRLRMETKLT RREVDAWFSE RRKMPVDSDG TEELEREMVK APSSGQEART PSSGRKIMKK
TPEQLHVLKR AFVRTQWPSA EEYDKMAKES GLPRTYIVNW FGDTRYACKN SNLKWYYLYQ
SGKVNEAMNG GELKKKPRKR FRGWSRRTRR PYPCKQTPPT IKVKTGKDIL KEHYLKHKFL
NEKDLDELVA KSSMSYEQVR DWFAEISRRE EKGLDPFIDG KEETHGDSEG EMEVKEKGDD
EENDIDNKDD ENNNDEDETN DNETTEEPQC FKQSQSESED Q
//
