ID A0A1S3M2R2_SALSA Unreviewed; 5472 AA.
AC A0A1S3M2R2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Microtubule-actin cross-linking factor 1-like isoform X18 {ECO:0000313|RefSeq:XP_013997370.1};
GN Name=LOC106570016 {ECO:0000313|RefSeq:XP_013997370.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013997370.1};
RN [1] {ECO:0000313|RefSeq:XP_013997370.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013997370.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_013997370.1; XM_014141895.1.
DR OrthoDB; 5489926at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 15.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF25; MICROTUBULE-ACTIN CROSS-LINKING FACTOR 1, ISOFORMS 1_2_3_4_5; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 21.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 34.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 29.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 36..172
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 185..289
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 865..926
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 5056..5091
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5092..5127
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5132..5210
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 2989..3015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4954..4998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5266..5472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 712..746
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1016..1074
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1159..1213
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1402..1432
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1508..1535
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1615..1677
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1704..1768
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2408..2435
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2887..2949
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4954..4975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4977..4998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5277..5321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5359..5388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5410..5441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5472 AA; 616670 MW; 0B1C1309A0BD8C1D CRC64;
MAGFIPGLQP TSHSQEKEFA QAYEDVLERY KDERDRVQKK TFMKWVNKHL IKVRKHITDL
YEDLRDGHNL ISLLEVLSGV TLQLKGVSSL RRVCISRAPP LILLGGEEVE DGAQGPREKG
RMRFHRLQNV QIALDFLKQR QVKLVNIRND DITDGNPKLT LGLIWTIILH FQISEIYVSG
ESGDLTAKEK LLLWSQQASE GWPGLRCTNF SSSWSDGRMF NALLHRFRPD LIDMEVVAQQ
SNLDNLEQAF EIAESLGVTR LLDAEDVDVP SPDEKSVITY VSSIYDAFPK IPEGGEGIAA
HEVDHRWAEY QSRFSTLLQW SRQHTTLMAN KNFPLNPVEL KALYNEYVHF KETEIPAKEL
EKSGVEHLYK LLEVWMEFGR IKLPLGMHPN DLEEEWGKLI LEMLEREKAL RPAVERLELL
LQMANKIQNM ALDCEEKLTL AKNTLQADMS QVESGEAVRC ERELGLYLQD CEVLIRRLNV
DLHVLRDQKY YQVEQLAFRV SCLHEELVSL RLQCSSVYRK GHFSPVTGGD RTAPRGSDSG
LSLSTGAQTL LGAVGVMGAA LLRRPMSRSQ LVAMSSSEDE GSLRFVYELL GWVEETQDVL
ERAESGADLP SVEQHLQDHQ NIHTAVEELL HSLKEARNYE TKVSRNFRSN YSDTLAKLEQ
QYCKLMENSS WRMRCLESLH AFVSRCTEEL IWLNEREEEE LAYDWSHNNT NVNAKRDLYA
EMRSELEEKQ EVMHSLQETA DRLCQENHPA KQTVEAYSAA LQTQWQWVRQ LCVCVEQHLK
DNTAYFQFVS DARDCETYLR QLQDTIKRQY TCDKNSRLGK LEDLLQDSME EKEQLIEYRS
SVASLVGRAK TVVQLLPRSA ESTLGSTTPI RAICDYRQIE ANVQITISRG EECVLEDNSQ
RTKWKVISPS GNEAMVPSVC FTVPPPNQEA MATASRMEQL YQNVMSLWHN LHVSMKSVVS
WHYLQKDIRT VSSWSLDTVR SQTPVARDQA LNHLEAHLAD FLSDTKESAL FTPAERRELE
RDAHTAQEHC QDLLVNMETV EKDESVSRSY LSELQNIKLR LEEAEQKLMR GIQTLPPSNL
SGNSVDNTVQ IAEQEKLQSD LDGLRTSLGE VSRRCVSFFE EKPTSSSVPV LRSELNLAVE
KIDRLHNLSS VYLRKLKTVD VLIHSLQAAE SQVKRYESRL SEEDIVPADA NAIQALREQL
GTWQSELEDQ EGVLSSLQSG VQKARETGTQ LNRLHPDRSP ELERYQERAA QLTERWAGVK
RQMDTRRAEL QALGSVLQQY RDGHSALIHW IEETTERQEN TQPGQTDSKV LSEQLAEQTA
LVAAIEKNQT KLDECQTHSK QYCTSVKDYE LQLMTFKAFV ESTQKSTVKR RRMHSSSDAI
TQEFMDLRTR YTALVTLTTQ HVKYISDALR RLEEEEKEVE EERQQRVGQV SELLGWVKGL
QGASAESSIA AQQAVGEQLA AKKEEVAQAI RNTQVFLMSK QASKLSPEER VQVTSQLDEL
TATYSQLCDH STARLQQLEQ EQAKEEQRKV VQQQKAECSQ KLEGLTMWLA GAASVLANQR
AGAESGDVNV LQQKQSELKE VQKDLQTRGE GVAETIRSVE EFLAEHGDSL SPEDRANLQG
ALSRMKEQYS ALTNTAYSSL AQLDTAISTT VQQNTQRAKA VEQLQETRGQ MDSLLEELSS
LNQPGKIGTG MTVTDHPSSP EGRLQSHSDM LQAELQQLQA QQAQLMQVSQ NARSLLDQPD
LAVPAEEKRR LRDQLDQLQT QHQEKLRSCQ ERLRRSEALK DELDKFLQEH GGLGTWLEQS
EGELCSLGEG ETDAQGLKGR LEEHKKLAED VICHKADLRF VSISGQKVLD SVQGALEKVG
GSDPALGETR QLVTDKLQDA NHRYIALHTK SSDLGGRLSG LLERYQQYQD EAVSLHTWLS
AQEQNRSIAG PSGETDSQTL QNTLRGIQLL QDELAERSVQ LEKVRRAGRE LANTQESPTL
RAAEIISTAD GLEKRFSSLS ESVSERAEQL QTSVAQSVSV QEGLKGLLAW LDGLLLTPGP
VQPTAQAVQD ALTQNQKLRQ ELLSRQGSVE ATCDSVSKLL QSSDASTASG LQGSLESLTR
HYAAAQAKQA EREAELRGLL PKLENYERLS TDLQGFTQTR LRALSPAGQP DRSVEDYRQT
IEEVRAEQEQ EAGHLKLFCQ LGTDLSQAKA LTSTQTLLDN VREVSDEFAR LESNITERNN
AIQSCEQRLG QFRSLSGSLL RWLHTTQEQL PPKEPNLNTE ALQRRVQQLK DLLSDWEAQG
VRVLELNKTG SELETLIINI TAPHAKTGVP QINGADSPSR VNGIHTCKDL TEMQVAVAEV
NGRYEELGGE LKNRRGHQEA SLELRQKASQ GTEELSRWLG DRENSLHLGQ TTTSPSKPEL
VRAQAQENKA LLSELAEHSG KVEELKSTLE KLIADNPDSP EADTWRQQMK EIDSRWAKAN
ETAVQRQTEL ETCADRLGSF ATAASQLGPW LREKELMMSV LGPLSIDPNM LNTQKQQAQF
MLREFETRRP QFDQLTQAAE GILSPSGGDS SPQDAKDLAE VRSELGSISQ QWDDLTQRLS
RRSEHIDQAQ GTSERYQALL KDLSVSVGAL GERLDGQASL SAQPEALKRR LQETGEIRSE
LEQRRDELSE AEKLCGELSA IVVEPYLRDE LKKRLESVSS PLRSLEERAT DGLSQLQAAL
SSTQQFQQMF EELRSWLDNQ GGQRDSTADS LPCQPEAIRN LFAQQDELHR GVASQRGPYE
LIQAEGASLL AKLPAGGEER SALQSRLATL RQDWDELNQC IVERQNRLKT ALTKAESYQQ
HRAKLTPWVT ECEKREADIQ PSLDPAALDE ALQKARQLGL DLEHHRPLLE GLNTAADQLL
EHCRVGEEDI RDEKAQLNRR VDGLAEKIQN CVSQLEELAG RLKEFEDGRQ AVERRLEAAR
HQIEVQEALG PQACSNKSLE RLKSQQETLH SLQPQVAYLR DLAQGLVQDA PHTAGGGGEG
GQRLEQQAQD TDREFGDVSE KIEKCCSTLE SRLQGVGEVQ SSVRDLFSRL ADLDDELDSL
SPVGRDADSL ASQADAVRTF LARLATLRSE LEGHGGDCTA MLRREGSSPD LLALRRETEA
LSRQAGKLAE RGQARLEQIE AAAEKVGEFY TQVAELQGLM GQAEDGVNSQ GVVGTEVETI
KQQLHEFKAV EREQVDSIQP KLQHVNAVGQ GLIQSAAKHT DTQALEHDLE TTNLRWNSLN
KRISERIAQL QEALLHCGKF QDALEPLLSW LSDTEELVAN QKPPSAEYRV VKAQIQEQKL
LQRLLDDRRA TVQMIQGEGE RIAATAEMQD KDKIQKQLEI LGERWGELLE KARARQCQLE
ELQTLALQFH EAAEPLGEWL SATERRLGTS EPMGTQTSKI TQQITKHKAV QESISSRGSE
VDRLEALGQS LAPLSCAADR DWLRERVGAV RLGHSELSDW CQRRAVMLEQ ALANAQLFGE
DEVEVLNWLA EVGQRLGQVS VQSYQPGVLT QQHKHTLSLN EEIVSRKKQV DQAIKNGQSL
LKQTTGEEVL LIQEKLDGIK SRYAEMTGGS SKALRILEQA LQLSTRFASA HDDLNQWLDK
VEAELNVMEP DATPAYQDRQ KELKCVSAEK RLVLDTVNEM GSALLDLVPW RAREGLDRLV
ADANQRYRTA DETITQRVKL VQAAVQRSQQ YEEMVDAELT WAGETERKLS SLGPLSLEPD
VTVAQLQVQR AFNIDIIRHK DTVDQLLHTR DDILETCSDQ QRDALMVKTD SLSARYEVVS
QRHQERFSAL EQAQVLVARF WETQEELEPW LGETETLIAQ LPPPAIDTEA LRLQQEQMRL
LRESIAEHKP HIDKLLKIGP QLAVLSHQEG ATVRQRYSDA EKRYTAIKEE VKGRAATLDE
AMSQSAQLVE FHDKMDPLLE TLEGAVQRLR SPSPVAAEAD KIREQLAEHK ATGLELDKLL
PSFSALCARG EELISRAAHD DPAAEAVRSR LLRLRSLWDE IRQRAEEREG KLTDVLDLAG
KFWADMAALL STLRDSQDIV RELEDPGVDP SLIKQQIEAA EAIKAETDGL REELEFVRTL
GAELIFACGE TEKPEVKKTI DEMNSAWEGL NRTWRERMER LEEAMTASVQ YQDALQGMFD
YLDNTVIKLC DMSTVGTDLG TVKQQIEELK QYKVEVYQQQ IDMEKLCHQG ELLLKKVSDQ
TDRDMIQEPL TELRHLWDNL GDKIIHRQHK LEGALLALGQ FQHALSELQS WLSHTHATLD
TQRPINSDPK AIEIELARHH VLRNDVLSHR STVETVNAAG AELLESSPGE EANHLRDQLD
HLNRGWENLL LKTQDRQKLL EAALHKAEGF HGELEEFLQW LRRTESQLSA AKPTGGLPET
AREQLQQHLE LQTQLARRAE QYNRLLDAGE SMLLSRGGEE GGPGAGTTQT QQNLALLQNK
WASLNTKMDD RRAKLDEAVS LATGFQSSLQ DTINWLTQAE QTLNMAQAPS LILDTVLFQI
DEHKVFVNEV NTHREQVLAL EKAGSQLRFA SIKQDVVLIK NLLLSVQARW DKLVQRSLDR
GRHLDEARKR AKQFHEAWRK LSDWLEEAES RLDSELEISN EPDKIKVQLT KHKEFQKALG
SKQPVYDTTV RSGKAMRDKA TLPEDTQKLD HLLGEVRDKW DTVCGKSVER QHKLEEALLF
SGQFAEALQA LVDWLYRVEP QLAEDLPVHG DLDLVSNLMD SHKAFQKELG KRTTSVHALK
RSARELMETG RDDTAWVKVQ LQELSNRWDT VCALSVTKQT RLQHALKQAE EFRMAVQLLL
EWLSEAEQTL RFRGVLPEEA ETLQTLLHTH RNFMATVEEK RTDVNRAAGQ GEAILTTCHA
DCITTIKHWI TIVRSRFEEV LTWAKQHEQR LETALTELLN NATLLEELLS WLQWAETTLV
QRDGETLPQD IPQLKTLITE HQVFMEEMTR KQPDVDKVTK TYKRKPAEPP SSLAERRGAR
KNQQQQQPQQ QQAAMQVAGG NPRLTQLCSR WQQVWLLALD RQRKLNDALD RLEELKEFAN
FDFDVWRKKY MRWMNHKKSR VMDFFRRIDK DQDGKITRQE FIDGILASKF PTSRLEMTAV
ADIFDQDGDG YIDYYEFVAA LHPNKDAYRP TTDADKIEDE VTRQVAQCKC AKRFQVEQIG
ENKYRFFLGN QFGDSQQLRL VRILRSTVMV RVGGGWMALD EFLVKNDPCR VQHPGLKILR
SDSSSTISSR IVTVTPGYFC CRARGRTNLE LREKFILPEG ASHGLAAFRS RGRRSKPGSR
TASPTRSSSS ASHSAHSCAS LPSAPATPTA SSRSSNSRGY AKPWLAHSKT PTPTKCQSCP
DHDHTTPGHE GAASGSKLKR PTFHSSRGSL TGENGGATPI STKPGRTDPK RTPSGASGPV
SRAGSRAGSR AGSRASSRRG SDASDASELL ETRSACSDTS DTPRLPGAAK PSKIPTISKK
APSPKTPASG KK
//
