ID A0A1S3M2T3_SALSA Unreviewed; 1537 AA.
AC A0A1S3M2T3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Brain-specific angiogenesis inhibitor 1-like {ECO:0000313|RefSeq:XP_013997528.1};
GN Name=LOC106570082 {ECO:0000313|RefSeq:XP_013997528.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013997528.1};
RN [1] {ECO:0000313|RefSeq:XP_013997528.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013997528.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013997528.1; XM_014142053.1.
DR KEGG; sasa:106570082; -.
DR OrthoDB; 4181250at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF39; ADHESION G PROTEIN-COUPLED RECEPTOR B1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1537
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010219141"
FT TRANSMEM 907..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1014..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1053..1076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1097..1119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1125..1149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 537..607
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 909..1150
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1189..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1537 AA; 170055 MW; 56153C82B4CCC742 CRC64;
MAWSPPRSGP LVALVALLFL GLTSSIPSGP ASDTCATLEQ SRFFGLFSST ANLPSTPCSW
TLQNPDPRRY TVYMKITKPS DSCLPRQVKT FQFDSFIETS RTYLGMESFD EVVQLCDAST
SVTYLESSKQ FLQLRKVAPR HGLEIVEGES SGEFKAEFLV VGKRNPSMPA CQKLCQWLEN
CLSTSTHPNP CGIMNTPCQC WETPVRKPGG CYRGGVYLEK CIPTPRDIGR DIVRDTEIIK
GWNGWGRWSE CSMECGGGVQ VRSRACHPED SVCEGVVEEG RACNPQPCIG QVRARSQALA
SIVGLKRENA DVPSTGVVAP QTVDAAAVAD EWSPWSVCSV SCGEGWQARS RFCVTSSYST
QCTGPLRENR PCNNTMVCPV DGAWDEWSPW SLCSSTCGRG YRDRTRTCKQ PQNGGEPCKG
PIKQTKFCNI AVCPVDGAWN EWSGWTTCSA SCSNGTKQRT RECNGPSYGG SECRGDWRET
NNCFLKDCPV DGRWLSWSSW GSCSKTCGGG SQQRQRMCEG PYFGGEPCPG ERGELRRCNE
KRCPEPHEIC QEETDGDVVW KRTPAGDMAA VTCPTDSTGL TLRRCTLGAV GLAYWENPTY
IKCISKDYQD ISTLAQDGVD KAKKGLMADG ISEVISRLRA TSDEGTKYSG DLLSIMDVLR
NTTEIYKGAG YSLSNADVEN YAQTISNLLK EEHHDKWEEA QLMGANVKEF LQLVEDFVDM
IGMQMKDFQD IYEVTENLVL SIHKRPTAMT TDFTFPVKGW RGMMDWVRTS EEKITVSRDA
LSIDQSEGTT AFVTGIILYR NLSSILSFQS NSSVLNSKVV TVVVKPTPGL LSTPVEIEFP
HLHNDTINET CISWDESETS SLLGSWSARS CRAVAVDSFR TKCVCDRLST FAILARLNPD
MNMDKNLLPS VTLIVGCGVS SLTLLLLIII YVSVWKYIRS ERSVILINFC LSIICSNALI
LVGQTQARNK VVCGVVAALL HFFFLSSFCW VLTEAWQSYM AVTGRLRNRI IRKRFLCLGW
GLPALVVAVS VGFTKAKGYG TVNYCWLSLE GGLLYSFVGP AAAVVLVNMV IGILVFNKLV
SKDGITDVKL KERAGASLWS SCVILPLLAL TWMSAVLAMT DRRSALFQIL FAVFDSLEGF
IIVMVHCILR REVQDAVKCR VVDRKDDGNG DSGSSLQNSH HTQLMSDFEK DADSNRPGGM
NSSCEEKMPL PPQLPLPMSS NFHTLPSHTT KAHMQAVPEY SSHTLTLKRE KSRLHGGMDP
SSCGKPVYVC EGELFQQLDA NLARGQAEGS CPDGSGYLLL PNTTSTLRKA KEDPSKYNIS
VEHLPQTRLV HLSGPFAEPQ AAFGLKTLPS DRVSVSYSER DSPVQNIHNM SSESHITHSS
LGDTFDSMNS MMSKSETIST LSMSSLERQK SRYAELDFEK IMHTRKRHQN MFQDLNRKLH
HAEKQDRESP ASDSKSVRWS VSSGGSDKTN HSDKQLPQVE RPWEGVQRTQ HSPPAWVRKD
LEPLAASPLH MQQVEWEKAG ATIPMVSQDI IDLQTEV
//
