ID A0A1S3M4F2_SALSA Unreviewed; 1451 AA.
AC A0A1S3M4F2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106570261 {ECO:0000313|RefSeq:XP_013997861.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013997861.1};
RN [1] {ECO:0000313|RefSeq:XP_013997861.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013997861.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_013997861.1; XM_014142386.1.
DR GeneID; 106570261; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013997861.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1451
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010208256"
FT TRANSMEM 753..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..187
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 189..273
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 286..381
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 384..486
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 492..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 910..1141
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1061..1132
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1173..1438
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1354..1429
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 832..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1451 AA; 163266 MW; 04E61DB6E9061720 CRC64;
MYTGVFLLML LVGIYADTMD QGPTAGCTFD EDSDPGLCEY KQGQEDDFDW QLMRTYNWPH
STPDLLRGSF MMVNSSQHAA GQRAHLLLRS LSENDTHCIQ FSYFLYSRDG HSPGDLQLYI
RVNGGPRGSA VWNVSGSHGR QWHQVELAVS TFWPSEYQVV FEASVSAERR GYIAIDDILL
LNYPCYKVPH FSRLGDVEVN AGQNATFQCV ATGKTTETEP FLLERRNGVV VAASSIQRLS
HKRLMATFQV AAERGEQDLY RCVTESTRGA AVSNFAELIV RVPPTPIAPP QLLRAGPTYL
IIQLNTNSIV GDGPVIRREI EYRASQSPWS ETHGVGSLTY KVWHLEPDTE YRISVLLTRP
GEGGTGAPGP PLVSRTKCAE PMRALRGLTA TEIQPRQLTL QWEPMGYNLT RCHTYSVSLC
YRYSTPAGGS AGNNATVREC LSVERNQSHF TLRDLPPFRS VHVRLALENP EGKKESREVT
FQTEEDIPGG VAPESLTFTP LDDMIFLKWE EPVEPNGVIT QYEISYQGIE SSDPGINVPG
PRRTVSKLRN ETYHMFSGLH PGTTYLVSVR ARTAKGFGQT ALTEITTNIS APVFDYEDVP
APLSESESTI TVLLRPALGR GAPVSAYQVV VVEEDGSRRV RRSRRRRREL GSGSDCFPVP
ASQVEAQSKS HYYTAELPPS SLPEATPFTV GDNHTYNGYW NTPLDPSKNY LVFFQAISNF
RGETRMNCIR IARKGACKDH KRTLEVSQHA EDMGLILGAC AGGLVVLILL LGAIVIVVKK
GRKKVALNKA AMSYRQEKTR KLGSLDCSMT EQSTLQQDER TANSFMDAHA CNTRNEQRSS
VNESSSLLGG SPRRHCRRKS SPYHTGQLHP AVRVADLLQH INQMKTGEGY GFKQEYESFF
DGWDVTKKKD KTKGRHDSLL GHDRHRVKLH SLLADPNSDY VNANYIDGYQ RSNHFIATQG
PKQEMIYDFW RMVWQENCFS IVMITKLVEV GRMKCCKYWP EDSELYGDIK ITLLKTETLA
EYTVRTFAME RRGYPAKHEV CQFHFTSWPE HGVPYHATGL LAFLRRVKAS TPPDAGPVVV
HCSMGAGRTG CYIVLDVMLD MAECEGVVDI YNCVKTLCSR RINMIQTEEQ YVFIHDAILE
ACLCGETAIP VIEFALTYKE MLRVDSQSNT SQLREEFQTL NSVTPHLDVE ECSVSLLPRN
REKNRSMDVL PPDRALAFLV TTEGVAEGNS YINAALTDSF HRPAAFVVTP HPLPGTTADF
WRLVYDYGCT SVVMLNQINQ SNSAWPCLQY WPEPGLQQFG PMTVELLSMM ADDDVIIRLF
RVQNIMRLQE GQLVVRHFQF LRWSPYRDVP DSKKAFLSLL AQVHNWQREC GEGRTIVHCL
NGGGRSGTFC ACTMLLEMIR HHSVVDVFYA AKTLRNSKPN MVETMEQYRF CYDLALEYLD
ALDCLSEIEV R
//
