ID A0A1S3M7R4_SALSA Unreviewed; 1844 AA.
AC A0A1S3M7R4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Signal-induced proliferation-associated 1-like protein 1 isoform X1 {ECO:0000313|RefSeq:XP_013999227.1};
GN Name=LOC106571085 {ECO:0000313|RefSeq:XP_013999227.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013999227.1};
RN [1] {ECO:0000313|RefSeq:XP_013999227.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013999227.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013999227.1; XM_014143752.1.
DR STRING; 8030.ENSSSAP00000083097; -.
DR PaxDb; 8030-ENSSSAP00000083097; -.
DR Ensembl; ENSSSAT00000116860; ENSSSAP00000083097; ENSSSAG00000066784.
DR GeneID; 106571085; -.
DR KEGG; sasa:106571085; -.
DR OMA; IVWAIRA; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000087266; Chromosome ssa15.
DR Bgee; ENSSSAG00000066784; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF10; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 1; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 666..883
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 1022..1098
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1781..1808
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1578..1592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1844 AA; 199402 MW; 55401D7B0ADB17DB CRC64;
MTSLKRSQTE RSVGGSVPAS DEFYTRRLRL PNGGAPPPRS ESTHLTSSSS SGSSSSSTPG
VPKMGVRARV ADWPPKRDGT GGVWHITVDT DSPSSTMSSS GGGECGSGGS AGERGSAGER
GSAGERGSAG SGERERSSGS GSATTAHSNL SAKLGHLISP QDSSMLRNIH NTLKSKMHHS
RHHSKDNRYL SPDGYQGSPR KGMRRIRQRS NSDITISELE GDGGEGWSFS GWTPMHREYG
STSSIDKHAG SGESFFDMLK GYTSQEAPDQ RSPAPDRLGE LLTVAPHKQA ALDLPDGPQG
PTRGSPASRL KEREKHLKRR SKSETGGESI FRKLRSVKAE GDSSRAGSDV EDGGREDVIG
PPPKPWSCQK GFAHFDVQSI LFDLNEAIQG RQSGGKRKNT TTGASAAAAA SASATSSLSS
NQSGVCGGGG SPCGSQEELS GKEAGAGQGG THTTNPALDP GDEKSNDLVL NCPCFRNELG
GEGERNIGLS KRQGSIGSGG SSSGSGGGSG SEEGPLETSL PHFTNAGVSV LEAPKDGQGQ
HADRAKRSVE HCDLGSYYYR KYFYLREHWN YLGVDETLGP VAVSLRREKL EEHKEHGQQY
NYRVIFRTSE LTTLRGSILE DAVPSTSKHG LARGLPLKEV LDYLVPELNA HCLRLALNTP
KVTEQLMKLD EQGLSFQLKV GVMYCASGQS SEEDMYNNDS AGPALEEFLQ LLGERVRLKG
FTKYRAQLDT KTDSTGTHSL YTTYKDYEVM FHVSTMLPYT PNNKQQLLRK RHIGNDIVTI
VFQEPGAQPF TPKNIRSHFQ HVFVVVRAHQ PCSDNTSYSV AVTRSRDVPS FGPPIPEDVS
FPKSSVFRDF LLAKIINAEN AAHKSQKFRA MATRTRQEYL RDLAERHTTS TPIDPSGKFP
FISLAHKRKE KSRPYAGAEL RSPGAITWAV HAEDHGAGGE LEALLAISND FLILLDQEAK
AVVFNCATKD VIGWTLGSPA SMRIFYERGE SVSLRSVSNN TEDFREVVKR LEYLTKGCET
SEMTLRRNGL GQLGFHVNYE GIVAEVESYG YAWQAGLRQG SRLVEICKVA VATLTHEQMI
DLLRTSVTVR VVIIPPHEDA TPRRGCSELY RMPVVEYKGS GESGSFDYKF PFRSKDNKWQ
RTSSSPQQSL TASPQPHTPN RAVSLGSSGG KTLSAERPER NAAIPRSVSS DGRPLDTKRM
SPGSENYAVT SSLALGRSPH NRSSPSNLSC STDPSQGSQH WRTQKSMPEG FGERRQHSPL
STERQVVGEG GASSKSTPNW PRVEEGGGSD RGSTDSPVSK SGPGYSGAPR IQRQEQVIHH
SPKKSSQPEG PYSSSNTLSS TASSGGHSDT DKWSDLGGPG APGEATDSEP NGLGGGYLHG
ASADSGIDTS SYGGGHSHPH HGSSSCLLAP GGREGRDRAP SPWHSPTEGD RRVLERSTPA
AESPQPPVER GERGEGTART PPTHLLVRDC SLYSLSDAGS HSSSRGHSGH SSPREESSSS
ATSPCSQTSV SPGPKTFYPR QGATSKYLIG WRKPGSTINS VDFGDNRRKS PGESGGEGGG
GGGQSRPHHS PQPHLTHAKT TAEDDMKRLS PDSPLKHRRH KVKEKSSSGQ PPTRRSLHRT
LSDESIYRGQ RVPSLKLGDL EPDPSLASNV LFSCSTLPRS PTTRGVPLRR PSYKLGIKLH
GDLSASDTSL AEMAERHRHP LPQELMPLPP SESRDSPLDW THLVDVASTF EIQRGFVFSD
SNPRGSGASS PHQTQPSLEI QLGPLSRPSS SEGPAGLERK LTKLEAMVRM LQDDLKKERE
EKQRLHLQIK MLWEDNQRLQ EESQSSAAKL KKFTEWVFNT IDMN
//
