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Database: UniProt
Entry: A0A1S3M7T8_SALSA
LinkDB: A0A1S3M7T8_SALSA
Original site: A0A1S3M7T8_SALSA 
ID   A0A1S3M7T8_SALSA        Unreviewed;      4850 AA.
AC   A0A1S3M7T8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 3-like isoform X1 {ECO:0000313|RefSeq:XP_013999252.1};
GN   Name=LOC106571102 {ECO:0000313|RefSeq:XP_013999252.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013999252.1};
RN   [1] {ECO:0000313|RefSeq:XP_013999252.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_013999252.1; XM_014143777.1.
DR   GeneID; 106571102; -.
DR   KEGG; sasa:106571102; -.
DR   KO; K04963; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013999252.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4204   4226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4400   4420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4452   4478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4602   4627       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4650   4672       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4731   4754       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    160       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      167    212       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      220    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    335       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      346    403       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      606    804       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1020   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1261   1469       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3936   3962       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3404   3424       {ECO:0000256|SAM:Coils}.
FT   COILED     3597   3617       {ECO:0000256|SAM:Coils}.
FT   COILED     4119   4143       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4850 AA;  548745 MW;  50DEC45C12C0BAAB CRC64;
     MAEGGEGEDD IQFLRTDDEV VLQSVATIQK ENRKFCLSVE GLGNRLCFLE PTSEAKYVPP
     DLCICCFILE QSLSVRALQE MLAHTVPNNE GKADHEQWAA QGGGHRTLLY GHAILLRHSF
     SGMYLTCLKT SRSLTDKLSF DVGLQEHSIG EACWWTIHPA SKQRSEGEKV RIGDDLILVS
     VSTERYLHLS ISNGSFQVDA SFMQTLWNVQ PTRSGSNVAV GFLCGGHVMR LCHGHDESLT
     IPGSEASEME QRIVNYEMGK GTSKARSLWR LEPLRIGWSG SHIRYGQAFR LRHLSTGHYL
     ALTEEQGLVL QERDKSDTKS TAFCFRATKE KIESGTKNRD IEGMGVAEIK YGDSACFVMH
     VATGLWLSYQ TPDAKASRIG PLKRRACLHA EGHMDDGLTL QRCQHEEARA VRIIRNTTVL
     FSHFIKGLDS IGRDKNVEVS MPNFDEVLQT LDDLIEYFKQ PDSELEHEEK QTLLRSLIKR
     QDLFKEEGML TLLVMCIDRL NLYNSAAHFG EHAGEKAGAA WKNILNLLYQ LLASLIKGNR
     NNCTQFSRNL DWLVSKLERL ESSSGILEVL HCILIESPEA LNIIQKGHIK SIISLLYKHG
     RNHKILDVLC SLCVCNGVAV RANQNLICDH LLPKRDLLLQ TRLVNDVQSM RPNIFLGVAE
     GSAQYKKWYF ELMIDQVDHY VTSEPTHLRV GWASTKGYAP YPGAGEGWGG NGVGDDLYSY
     SFDGLYLWSG RIPRAVASIN QHLLNSDDVV SCCLDLGAPS MSFRINGQPV QGMFEDFNTD
     GFFFPVVSFS AGVKVRFLLG GRHGDFKFLP PAGYSPCYEA LLPKEKMRVE AVKEYKRDHG
     GVRDLLGTTQ ILSQASFIPT PVDTSQIVLP PHLDNVRDRL AENIHELWGM NKIELGWSYG
     KVRDDNKRQH PCLVDFTKLP ETESNYNLQM SSETLKTLLA LGCHVTQTNV NAEEDLKKVK
     LPKDYVMSNG YKPTPLQLSE VKLTAGQEVL VDKLAENAHN VWAKDRVKQG WTYGIQQDVK
     SRRNPRLVPY ALLDERTKKS NRDSLREAIR TLVGYGYDID PPDQEACHIV ERQSIETIRF
     FRVEQTYAVK TGKWYFEFEA LTGGDMRVGW ARPGCRSDFD LGMDDQAYVF DGYKGRRMHM
     GARFFGQSWN KGDVVGCMIN MEDKSMVFTL NGELIITNKG SELCFVDFET EDGFIPVCCL
     AQSEIGRMNL GKDASTFKYY TMCGLQEGFE PFAVNMNREV TMWFSKRLPT FVNIPKDHNH
     IEVTRIDGTV DNPPCLKVTH KTFGTQQSNS DMLYCRLSMP VELHVPHVSA DESQKLSQPP
     KEDGYGSITT YYHSVRVFAG QDPASVWIGW VTPDYHYHSK HFSLNKTRTV TVTLGDERGR
     VHESVRRSNC YMVCAGDVVG SSHSSSRSNI DLEIGCFVDL ATGFLSFTAN GKELATTYEL
     ESNSKLFPAV FVRPTSTNLF QFEFVKIKDA MPLSSAIFKS EQRNPVPQCP PRLDVQTIVA
     VLWSRMPNTF LTVETARVSE RHGWVVQCLE PLQMMAVHIP EENRCLDILE LSEVESLRKF
     HYHTLKLYCA LCALGNTRVA HALCSHLDQS QLLYTIDNQY LSGMLREGFY NVLMSIHLET
     AKEARLMMNN EFIIPVTDET RSIKLFPDES KRHSLPGVDL STSLKPRLNF SPLSFITTKK
     QQHLYSPQIP LGILKEKAIS MLTEAVQGGG SHIRDPVGGS VEYQFVPILK LIGTLLIMGV
     LTSEEVRLIL LLIDPNVFGE PEDEEAKVEE VEAAAGGGEK EEVSSNEVKA VEAGEEETKE
     VKMSVKGLLE KTLPESVKRQ MCELLHYFCD CELKQRIEAI VSFSDSFVSK LQYNQKFRYN
     QLMLALNMSA AVTAKKTKEF RSPPQEQINI LLNFAAGEDC PCPEEIQEDL YSFHDELRLH
     CGIPVEEEEE EEDTSIKGRL LAMLYKIKGP PKKLEEEPTE QEQAAPTNLK ELISQTMASW
     AQECSIQDPE LVRVMFSLLR RQYDGIGALL RAMRKSYTIS AASVQDCVNL LASLGQIRSL
     LSVRMGKEEE KLMIDGLGDI MNNKVFYQHP NLMRVLGMHE TVMEVMVNVL GGDKSQEIAF
     PKMVASCCRF LCYFCRISRQ NQKAMFDHLS YLLENSSVGL ASPAMRGSTP LDVAASSVMD
     NNSLALALEE PDLEKVVTYL AGCGLQSCAM LLAKGYPDIG WNPIEGERYL SFLRFAVFSN
     GESVEENSNT VVKLLIRRPE CFGPALRGEG GNGLLAAMLE AIKISEDPAL DLPSTAEGEP
     TGSGEEEEEE VVHTGNAIMS FYSALIDLLG RCAPEMHLIN KGKGEALRIR AILRSLVPTT
     DLVGIISIPL KMPIVNKDGS VTEPDMSASF CPDHKAPMVL FLDRVYGVED QSFLLHLLEV
     GFLPDLRASA SLDTDVLSTT ETALAMNRYI GSALLPLLTR CAGHFSGTEH YAALIDSTLH
     TIYRLSKGRS LTKAQRDSIE ECLLAICKHL RPSMMQQLLR RLVFDVPLLT EYCKMPLRLL
     TEHYEQSWKY YCLPSGLGSS GMASEEELLL TKKLFWGILD SLSTKKFDSD LFKTGMACLC
     ATAGALPPDY VDASPGATLE KQASVDAHGN FDPKPINTAN ISLPEKLDYI ANKFAEHSHV
     KWSSEKVTAG WKMGESVDDK AKTHPLLKPY KSLSEKERET YRWPVKESLK SMLAMGWNME
     RTKEGEAMFI EKQSKISEST QDNDNEFIPE PPLDLNNITL SRELQGMVEV VAENYHNIWA
     KKKKTELNSK GGGSHPLLVP YDTLTAKEKY RDREKAQDLF KFLQINGYIV TRDLKDMEPD
     SSSMEKRFAY TFLKRILKYV DSAQEFIAHL EAMATSGKTD KSPHDQEIKF FAKVLLPLID
     MYFKNHSMYF LSSPSKNLSS SGYASNKEKE MITSLFCKMA ALVRHRISLF GSDSAIMVSC
     LHILAHSLDT RTVMKSGSEM VKAGVRTLFE NAAEDLEKTL EMLKLGKFSQ SRSQMKGLTQ
     NITYATTALL PILTALFEHV TMHNFGVYLL VDDVQLSCYR IVTCLYSLGT GKHIFIERHL
     PALGECLATL VGAMPVAFLE PDLNAHNPLS VFNTKTPRER AILSMPDSVE EMCPEMPHLD
     RLLKDINDIS ESGARYTEMP QVIEVILPML CTYLSYWWER GTENSAPHTA CCTTVCSHHL
     SIILGNILKI LNNNLGIDDA PWMKRIAVYS QPIICKAAAD LLRSHFLPTL EKLRKKTVKV
     VAEEELLKAD IKGDTQEAEL LVLDEFAVLC RDLYAFYPML IRYVDNNRSR WLKRPDAQSN
     ELFTMVAEIF ILWCKSHNFK REEQNFVVQN EINNLSFLTG ESKTKMSKSG GDQDRKHKKR
     RGELYSVQTS LIVAALKKML PIGLNMCTPG DQELISLAKI RYSLKDTDEE VKDHLRENLH
     LQDKSDDLAV QWQMNLYKDV VVESEERTDP EQTVDRVQSI SAAVFHLEQV EQPLRMKKCV
     FQKLLSKQRK RAVVACFRMA PLYNLPRHRS INLFVLGYVR LWIETEEYSF EEKLVQDLAK
     TPMKIVEEEE EEEVEIKPDP LHQLILHFSH NALTERSFLE EDPLYIAYAD MMAKSCAEDE
     EEEEEEEGKE KTFEEKEMEK QKILYQQARL HARGAAEMVL QMISASKGRL GPMVTCTLKL
     GISILNGGNV LVQQKMLDYL KEKRDAGFFK SLSGLMQSCS VLDLNAFERQ NKAEGLGMVT
     DEGSIDSERG SKVLTNDDFT KDLFRFLQLL CEGHNGDFQN FLRTQTGNTL TVNIIISTVD
     YLLRLQESIS DFYWYYSGKD IIDEAGQVNF SKALAVAKQI FNSLTEYIQG PCIGNQQSLA
     HSRLWDAVVG FLHVFANMQM KLSQDSCQIE LLKELMDLQQ DMVVMMLSLL EGNVVNGTIG
     KQMVDTLVES SSNVEMILKF FDMFLKIKDL TTSDNFREYD PENKGVISKK DFQKSMENQK
     QYTQSEIEFL LSCAEADEND MFNYEEFVER FHEPAKDIGF NVAVLLTNLS EHMPHDPRLA
     TFLEPAESVL NYFEPYLGRI EIMGGGKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV
     VNEGGESEKM EMFVNFCEDT IFEMQLASQI SEPDVVERPE EEEEEVHNLL EELAEEEENS
     ELEASSAFTM ACISVKKKIS NFRQMLTFKI LKKQYKKSKK LSLKEMTVGF FSFFWTLFTG
     FFKGIYSLIF GFFHLIWSSM FGGGLVEGAK NMKVTDILGN MPDPTQFGIH GDVLEMEKAE
     VGDSVSGGTD QAIKPSDKAE QDILMQMINP TPKKGEGLKH VDPGLGDVSE TPDTTATVEK
     KKAVKESKES EPEKADTEKK EKEDMAKEEE PKEEVAHEKP APKSRNGQSK DAPTSFFASF
     LAGLEIYQAK MLNTLARNFY NMRFLALFVA FAINFILLFY RVTADEDSWT SSDDDDEEGG
     EEYFVLEEST GYMAPTLCFL AVFHTALSIL CLIGYYFLKV PLVVFKREKG IARLLEFEGL
     YITEQPADDD ITGQWDRLVI NTPSFPNNYW DKFIKRKVIN KYGDLYGAER IAELLGLDKS
     ALDFDPTQET VVEAASLVSW LSSIDTKYHI WKMGVVLTDN SFLYLIWYAT MSILGHYNNF
     FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE
     DEDAPDMKCD DMMTCYLFHL YAGVRAGGGI GDELEDPAGD PYELWRILFD ITFFFFVIVI
     LLAIIQGLII DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTTPHGFET HTLQEHNLAN
     YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC FRKQYEDLLG
//
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