ID A0A1S3M9D6_SALSA Unreviewed; 1498 AA.
AC A0A1S3M9D6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106571353 {ECO:0000313|RefSeq:XP_013999802.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013999802.1};
RN [1] {ECO:0000313|RefSeq:XP_013999802.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013999802.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_013999802.1; XM_014144327.1.
DR GeneID; 106571353; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14636; R-PTPc-K-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF11; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013999802.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1498
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010373564"
FT DOMAIN 33..193
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 195..280
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 293..388
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 391..487
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 490..594
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 921..1200
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1120..1191
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1232..1494
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1408..1485
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1498 AA; 169138 MW; E148CC09889676B1 CRC64;
MDTCRLGFIL LYFSILRVGA QFTAAQMGQP VKGGCTFDDG PAQCDYQQDP YDDFDWTHVS
AQEVPYLSSE LPQGSYMMVD SSQHDAGEKA RIQLPVMKEN DTHCIDFNYL LYTQDGSSPG
TLNILVKVNK GPLANPIWNV TSYTGKDWLR AELAVSTFWP NEYQVIFEAE VSDGKTGFIA
IDDIQVLSYP CDKSPHFLRL GDVEVNAGQN ATFQCIATGR DTVNNRLWLQ RRNGEDIPVA
STKNINHRRF AASFRLKEVT SLDQDLYRCV TQSERGSGVS NFAGLIVREP PRPIAPPQLL
GVGPTYLLIQ LNANSIFGDG PIILKEVEYR MTSGSWIETH AVNSPNYKLW HLDPDTEYEI
RVLLTRPGEG GTGQPGPPLI TRTKCAEPMR TPKRLKIAET QARFIAVDWE SLGYNITRCH
TFNVTICYRY YNANNQTKAD CLDMDPKAPR HVVGNLPPNT NVSLKMILTN PEGRKESDET
IIQTDEDVPG PVPSQSMKAT PFEDRIFLYW KEPLEPNGII TQYEIAYSGI RSFDPSVPIM
RPPLIVSMPW NTSHHVFNQL HPGTTYQFII RASTVKGFGP PTILNVTTNI SAPTLEEYDG
SEAFLNETAT SITVLLKPAQ AKGAPISAYQ IVVEELNPHR TRREASSVDC YQVPVPFHSA
SSGGSPYYFA AELPPGNLPE PSPFTVGDNK TYHGFWNPPL APRKNYNIYF QAVSSVEKES
KTQCLRLATK GATEEPEVIP DPAKQTDRVV KIAGISAGVL VFILLVLVAI LLVKKSHGGF
TTKNWSVRRS YYSYSYYLKL AKKRKDAIGN TRQEMTHMVN AMDRSYADQS TLHAEDPMAV
TFMDSHNFSN RLPNDPLVPT AVLDENHTAA AAESSRLLDV PRYHCEGTES PYQTGQLHPA
IRVADLLQHI NLMKTSDSYG FKEEYESFFE GQSASWDVAK KDTNRTKNRY GNIIAYDHSR
VILQPMEDDP SSDYINANYI DVSGAASSIG ERVRHNRPSL IWLYRDGYQR PSHYIATQGP
VHETVYDFWR MVWQEQSACI VMVTNLVEVG RVKCYKYWPD DAEVYGDFKV TFVEVEPLAE
YVVRTFTLER RGFNELREVK QFHFTGWPDH GVPYHATGLL SFIRRVKISN PPSAGPIVVH
CSAGAGRTGC YIVIDIMLDM AEREGVVDIY NCVKALRSRR INMVQTEEQY IFIHDAILEA
CLCGETAIPA CEYKAAYYDM IRIDSQSNSS HLKDEFQTLN SVTPQPQPED CSIALLPRNH
EKNRFMDMLP PDRCLPFLIT IDGESSNYIN AALMDSYRQP AAFIVTQHPL PNTVKDFWRL
VYDYGCTSLV MLNEIDLAQG CPQYWPEEGM LRYGPVQVEC MSCSMDCDVI SRLFRICNLT
RPQEGYLMVR QFQYLGWAAH REIPASKRSF LKLILQVDKW QEECEEGEGR TIIHCLNGGG
RSGMFCAISI VCEMIKRQNV VDVFHAVKSL RNSKPNMVDS PDQYRFCYDL ALEFIETS
//
