ID A0A1S3M9I4_SALSA Unreviewed; 335 AA.
AC A0A1S3M9I4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Hairy/enhancer-of-split related with YRPW motif protein 2 {ECO:0000313|RefSeq:XP_013999847.1};
GN Name=LOC106571366 {ECO:0000313|RefSeq:XP_013999847.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_013999847.1};
RN [1] {ECO:0000313|RefSeq:XP_013999847.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013999847.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_013999847.1; XM_014144372.1.
DR AlphaFoldDB; A0A1S3M9I4; -.
DR STRING; 8030.ENSSSAP00000117952; -.
DR PaxDb; 8030-ENSSSAP00000117952; -.
DR GeneID; 106571366; -.
DR KEGG; sasa:106571366; -.
DR OMA; DTTPCRL; -.
DR OrthoDB; 5405528at2759; -.
DR Proteomes; UP000087266; Chromosome ssa15.
DR Bgee; ENSSSAG00000080631; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18920; bHLH-O_HEY2; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF88; HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 48..103
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 125..157
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 35989 MW; 2564A518E14BE81A CRC64;
MKRPCEDSTS DSDMDETIDV GSENNYSGHS NGSFVRCGSP TTTTQVMARK KRRGIIEKRR
RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG YFDAHSLAMD
FMSVGFRECL TEVARYLSSV EGLDSSDPLR VRLVSHLSTC ASQREAAAMT SSMAHHQQAL
HPHHWAAAFH PFPTTFLQQN GLPSSDSAAS RLSVEVPQRG SALLTATFSH TDSSHRAPSN
GSVAPCVPPL STSLLSLSAT VHAAAAAAAA AQTFPLSFPG GFPIFTPHSV SSTASMVASA
VSPSIFTTST SQQSRDRESS SSKPYRPWGT EVGAF
//
