ID A0A1S3MFC0_SALSA Unreviewed; 444 AA.
AC A0A1S3MFC0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Transcription factor E2F1-like isoform X2 {ECO:0000313|RefSeq:XP_014001898.1};
GN Name=LOC106572360 {ECO:0000313|RefSeq:XP_014001898.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014001898.1};
RN [1] {ECO:0000313|RefSeq:XP_014001898.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014001898.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_014001898.1; XM_014146423.1.
DR AlphaFoldDB; A0A1S3MFC0; -.
DR STRING; 8030.ENSSSAP00000110535; -.
DR PaxDb; 8030-ENSSSAP00000110535; -.
DR Ensembl; ENSSSAT00000145457; ENSSSAP00000110535; ENSSSAG00000078095.
DR GeneID; 106572360; -.
DR OMA; FAYVTCQ; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000087266; Chromosome ssa15.
DR Bgee; ENSSSAG00000078095; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF43; TRANSCRIPTION FACTOR E2F1; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 126..191
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 68..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 48690 MW; 303907B21E0A51BC CRC64;
MSEALVSGQT SEDLLADFES LLNAGSIDLS ENHQIVIIST PSNVGLNSAV PSNTGEILLF
ATPQGPADVV QDQRRPTLGR PPVKRKLDLD SDHQYVSTSR PPSLGRAPTS TPAPPRVPKP
STEKSRYDTS LNLTTKRFLD LLAQSPDGVV DLNWASQVLE VQKRRIYDIT NVLEGIQLIS
KKSKNNIQWL GNRIDGASVS RYQDLQKEVS DLTQAEEKLD ELITKCNFQL RLLTEDTQNK
KLGYLMCQDL RKSFDSPDQL VMVIRAPPET QMQVSEPSEG YQVSLKSTQG PIDVFLCPED
ISGVCSPVTG ISPSKATYQI MPQPAEQPQC SSTQEMTSST AASQQNSSPL PLFREAGAVL
ECDPFPNLGV LPEFDLSPLS SSDFLSGEGL GNPLDGFINL SPPQSHGYHF GLDEHEGITE
LFDSDFGDFT PLELGWRETP TEQE
//
