ID A0A1S3MFJ5_SALSA Unreviewed; 1007 AA.
AC A0A1S3MFJ5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN Name=iars2 {ECO:0000313|RefSeq:XP_014001952.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014001952.1};
RN [1] {ECO:0000313|RefSeq:XP_014001952.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014001952.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR RefSeq; XP_014001952.1; XM_014146477.1.
DR AlphaFoldDB; A0A1S3MFJ5; -.
DR GeneID; 106572330; -.
DR CTD; 55699; -.
DR OrthoDB; 656at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR Gene3D; 1.10.730.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.10.830; Ile-tRNA synthetase CP2 domain-like; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR HAMAP; MF_02002; Ile_tRNA_synth_type1; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033708; Anticodon_Ile_BEm.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR023585; Ile-tRNA-ligase_type1.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 97..705
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 750..866
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 1007 AA; 112398 MW; 4AB67C9F3338463A CRC64;
MLLCRISAVS QSVARWGTSV RRGTLLHPAL SFNSSRCQNV SSTEGTVHPA AAQGAGPYRD
SVLLPRTEFP MKLTGQKLID REVQIQQECG FAELYSWQRE RKAKKEYCLH DGPPYANGDP
HVGHALNKIL KDIQNRFEML RGKQVHFVPG WDCHGLPIEL KALGELGTSG LSPLQIRQKA
REFAEGAITR QRAAFQRWGV MADWDKCYYT FDGTYEAAQL KVFQDMHSKG LIYQDYKPVF
WSPSSRTALA EAELEYNPKH VSKAIYVTFA LATLPPKMAE AVGELGSISV LVWTTQPWTI
PANQAVCFMP NAQYSVVKRR DSSQLLLVAT ERVSSLATLL STELENVGTF TGAELEGGVC
QHPTIPRKEV PLLPANFVTM GKGTGLVHTA PAHGMEDYSV ASHFKLSVEC IVDEEGRFTE
LAGPELQSLS VMGEGNDTVI SMLKAVGSLV KEEECVHSYP YDWRSKEPVV IRPSKQWFIN
ITSLKDKAKE VLAKVRVIPE SARGSLLAHL DRRPYWCISR QRSWGVPIPV FYHKETGEPL
INKHTVSHVT QLFSEKGSDC WWELPLESLL PPEVLKKSKA GEVTDYERGD DVLDIWFDSG
TSWAAVLEDS RADVYVEGKD QIGGWFQSSL LTSVAVLKRA PYKALMIHDF VISEKGEKMS
KSLGNVVDPD TVIHGGEDPS VSPAYGVDVL RWWVAESNVF SEVQIGPNVL NSARDSINKL
RNTLKFLLGN LQGFDPRTQA VDPKEMHYID QYLLHLLRNY SMKMTDAYND FGAGRAIRLL
QAFITRDLSK FYFSIIKDRL YCDPEDSLGR RSCQTVLEEI LDGVTRSIAP ILPHLAEEVY
LHAPGHNEGE TLFRSGWIKS SPVWRRPGLE EAVEGACAIR DSFLSSIPGR NAAEYELTIE
IEPGLLFELI ESLQEEPTSS YSQLTELMMS SRTTLTSALP RDLPNDALIS NGSFLINLEG
GVIREDSAYQ VAAVPTSMAR CPRCRRYTSD SPDCPCPRCQ TVLARAQ
//