ID A0A1S3MFM2_SALSA Unreviewed; 455 AA.
AC A0A1S3MFM2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons protein 1 isoform X2 {ECO:0000313|RefSeq:XP_014001864.1};
GN Name=pacsin1 {ECO:0000313|RefSeq:XP_014001864.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014001864.1};
RN [1] {ECO:0000313|RefSeq:XP_014001864.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014001864.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection
CC {ECO:0000256|ARBA:ARBA00004316}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_014001864.1; XM_014146389.1.
DR AlphaFoldDB; A0A1S3MFM2; -.
DR STRING; 8030.ENSSSAP00000114197; -.
DR PaxDb; 8030-ENSSSAP00000114197; -.
DR GeneID; 106572344; -.
DR OrthoDB; 9421at2759; -.
DR Proteomes; UP000087266; Chromosome ssa15.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd11998; SH3_PACSIN1-2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF23; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Kinase {ECO:0000313|RefSeq:XP_014001864.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|RefSeq:XP_014001864.1}.
FT DOMAIN 13..283
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 396..455
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 173..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51210 MW; F4775B9447505A47 CRC64;
MSGSYDESAA AADDAMDSFW EVGNYKRAVK RIDDGHRLCN DLMGCLQERA KIEKAYGDQL
TAWSKRWRQL IEKGPQYGTV ERAWLGVMTE AEKVSELHQE VKNGLLNEDL EKVKNWQKEA
YHKQMIGGFK EAKEADEGFK KAQKPWAKKL KEMETAKKTY HMACKEEKLA ATREADGKTQ
ASVTTDQQKK LHEKTDKCKH DVQKAKEKYE KSLSELSAVT PPYQESMEQV FDQCQQHEVK
RLTFLKEILL DIKRHLNLTE NQSYSTVYRE LERTILGANT QEDLQWFSNH HGPGMHMNWP
MFEEYNPDAT AAVVKREKVQ KPAGAPPTPS TDHVAPPGDR GSVSSYEKNQ AYSTEWSDDD
APAAYSGGET NGGGNGNSFE EDSGSAGKGG AGTGTASGVR VRALYDYDGQ EQDELTFKAG
DELTKTEDED DQGWCRGRLD TGREGLYPAN YVEEI
//
