ID A0A1S3MIK7_SALSA Unreviewed; 155 AA.
AC A0A1S3MIK7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Thyrotropin subunit beta {ECO:0000256|ARBA:ARBA00039483};
DE AltName: Full=Thyroid-stimulating hormone subunit beta {ECO:0000256|ARBA:ARBA00042284};
DE AltName: Full=Thyrotropin beta chain {ECO:0000256|ARBA:ARBA00042931};
GN Name=LOC106572976 {ECO:0000313|RefSeq:XP_014003048.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014003048.1};
RN [1] {ECO:0000313|RefSeq:XP_014003048.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014003048.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin. {ECO:0000256|ARBA:ARBA00038688}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552}.
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DR RefSeq; XP_014003048.1; XM_014147573.1.
DR AlphaFoldDB; A0A1S3MIK7; -.
DR STRING; 8030.ENSSSAP00000049748; -.
DR PaxDb; 8030-ENSSSAP00000049748; -.
DR GeneID; 106572976; -.
DR KEGG; sasa:106572976; -.
DR OMA; RRCHCTR; -.
DR OrthoDB; 5353873at2759; -.
DR Proteomes; UP000087266; Chromosome ssa15.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF5; THYROTROPIN SUBUNIT BETA; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..155
FT /note="Thyrotropin subunit beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010331818"
FT DOMAIN 19..118
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
FT REGION 124..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 155 AA; 17548 MW; 597FEE48C0EE70AD CRC64;
MYVLAWVLLF VWLGGGVCVC MMENYTLLIE KRGCSQCIAV NTTICSGFCH TQDTNVKGRV
GKSYLIQRGC MPHSLVYHPA RVPGCPLHAN NVLYYPESRR CHCTRCDGHT HRCVHVTQVT
PTPCTRKNPA THRTSSSTRR TWKRPPVKKN SDQET
//
