ID   A0A1S3MJV7_SALSA        Unreviewed;      1259 AA.
AC   A0A1S3MJV7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Homeodomain-interacting protein kinase 2-like isoform X7 {ECO:0000313|RefSeq:XP_014003379.1};
GN   Name=LOC106573173 {ECO:0000313|RefSeq:XP_014003379.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014003379.1};
RN   [1] {ECO:0000313|RefSeq:XP_014003379.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014003379.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014003379.1; XM_014147904.1.
DR   AlphaFoldDB; A0A1S3MJV7; -.
DR   OrthoDB; 3095114at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa16.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14211; STKc_HIPK; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24058; DUAL SPECIFICITY PROTEIN KINASE; 1.
DR   PANTHER; PTHR24058:SF53; HOMEODOMAIN-INTERACTING PROTEIN KINASE 2; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; DNA-binding {ECO:0000313|RefSeq:XP_014003379.1};
KW   Homeobox {ECO:0000313|RefSeq:XP_014003379.1};
KW   Kinase {ECO:0000313|RefSeq:XP_014003379.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Transferase {ECO:0000313|RefSeq:XP_014003379.1}.
FT   DOMAIN          223..556
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          824..843
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..961
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..865
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        876..890
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        921..939
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         252
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1259 AA;  137146 MW;  71CE70F38DE952F4 CRC64;
     MAPVYEGMAS QVQVLSPHTL QSSAFFSVKK LKVEESSYWD MTGYGTHSKV VYSQNSKQQV
     SHATPLGINS SLPYEQPALI FPSSAGHIVV ASASSTSGTA GPLGPLLGLA GSSSGSGGGS
     GGGSGGAIHN LTRRSTVSLL DTYQRCGLKR KSEELDNSNS SVTIIEEHGS GTTMIQNAAS
     GAAVATATAT ATSTATSKNS GSNNEGDYQL VQHEVVCSMT NTYEVLEFLG RGTFGQVVKC
     WKRGTNEIVA IKILKNHPSY ARQGQIEVSI LARLSTESAD DYNFVRAYEC FQHKNHTCLV
     FEMLEQNLYD FLKQNKFSPL PLKYIRPVLQ QVATALMKLK SLGLIHADLK PENIMLVDPS
     RQPYRVKVID FGSASHVSKA VCSTYLQSRY YRAPEIILGL PFCEAIDMWS LGCVIAELFL
     GWPLYPGASE YDQIRYISQT QGLPAEFLLS AGTKTTRFFN RVTDSTNYPL WRLKTPEDHE
     GETAIKSKEA RKYIFNCLDD MAQVQSTVNM TTDLEGSDML AEKADRREFI DLLTKMLTID
     ADKRITPIET LNHPFVTMTH LLPHSTHVKS CFQNMDICKR RVGMYDTVNQ SKTPFITHVA
     PSTSTNLTMT FNNQLNTVHS QATNLAPSTT SATLSLANPE VSILNYPSAL YQPSAASVAA
     VAQRSMPLQP GAPQLCPARP DPFQQALIVC PPGFQGLQAS PSKHTGYSVR MENAVPIVTQ
     APGAQPLQIQ PGLLTQQAWP SGTQQILLPP AWQQLTHTSV QHATVIPDSM MASQPLANWR
     NSHQHSGHYN PIMQQPALLT GHVTLPSNQN QPLNVGVAHV MRQPLTNNNN SSSKKTKQYQ
     MTARNVSAYE VSSSQAVLSP QRSKRVKENT PPRCAVLQNH APSSSSGCGP PQGCGGWGAG
     EAEQASSTTQ DHHQHHNRPR QTIIIPDTPS PAVSIITISS DTDEEDDHKQ SNTNHTSLSK
     HRKNVISCVT VHDSPDSDLS SNNSPYAVES RLANNNGYHD SKTTLLDNYS NGNNPRTIII
     PPLKSQSSEV LSECERLMPD AMNHQNSAYK FKTSNGVGMM SGNNHLSGGM AYRQQRSGPH
     PFQQQQPLNL SQAQQHMVAE RNGGHRRQQA YITPTIAAQA PYSFQHHNSP SHTANVHTHL
     AATHLSATHL AATHLPGQPH LYTYTAAPVA LGSTGTVAHL VATQGSARHT VQHATYHTPG
     IVHQVPVSMG HGVLPSPTLH HSQYQAQFTH QTYISASPAS TVYTGYPLSP TKVNQYPYL
//