ID A0A1S3MM53_SALSA Unreviewed; 1624 AA.
AC A0A1S3MM53;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Low-density lipoprotein receptor-related protein 5-like {ECO:0000313|RefSeq:XP_014004308.1};
GN Name=LOC106573620 {ECO:0000313|RefSeq:XP_014004308.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014004308.1};
RN [1] {ECO:0000313|RefSeq:XP_014004308.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014004308.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_014004308.1; XM_014148833.1.
DR STRING; 8030.ENSSSAP00000065779; -.
DR PaxDb; 8030-ENSSSAP00000065779; -.
DR GeneID; 106573620; -.
DR KEGG; sasa:106573620; -.
DR OMA; HECLCPL; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000087266; Chromosome ssa16.
DR Bgee; ENSSSAG00000056819; Expressed in actinopterygian pyloric caecum and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 11.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 12.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|RefSeq:XP_014004308.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_014004308.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1395..1415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 125..167
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 168..211
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 212..254
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 303..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 390..432
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 433..475
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 476..519
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 520..562
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 609..646
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 692..734
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 735..777
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 778..820
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 821..862
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 910..947
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 1130..1172
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1222..1266
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1008..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..1624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1591..1605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1610..1624
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1286..1301
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1304..1316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1311..1329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1323..1338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1342..1354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1349..1367
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1361..1376
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1624 AA; 181833 MW; 1C8B580F9EB66AE5 CRC64;
MELKLRAIEM DVFLVELLFY SSLLSVGNGS PLLLFANRRD VRLVDVEMGR PESAVVVSDL
EDAAAVDFLY SEGLIFWTDV SEEAIKQTYY NQSTDSLKEA LGTRQTVVVS GLDSPDGLAC
DWLGRKLYWT DSETNRIEVA NLDGTSRKVL FWLDLDQPRA IALNPAHRYM YWTDWGEEPR
IERAGMDGSN RKIIVEVDIY WPNGLTVDLD EQKLYWADAK LSFIHRANLD GSSRETVVEG
TLTHPFALTL SDETLYWTDW QTRSIHACNK HTGDKRREIL SGIYSPMDIQ VLGSDRQPDI
HTPCSDSNGG CSHLCLLSPM QPFYSCACPT GVKLKEDGKT CRPGAEQVLL LARRTDLRRI
SLDLPDFTDI VLQVDDIRHA IAIDYDPVDG YVYWTDDEVK AIRRSRIDGT EAQTLVTTEI
NHPDGIAVDW VARNLYWTDT GTDRIEVTRL NGTSRRILIS ENLDEPRAIV LDPVNGYMYW
TDWGEKPKIE RANLDGMERL VLLNTSLGWP NGLAIDYEAG KLYWGDAKTD KIEVIDVDGS
NRMTLLEDKL PHIFGFTLLG DYIYWTDWQR RSIERVHKTN AIREIIIDQL PDLMGLKATR
VTEVSGTNGC VEDNGGCSHL CFHRPQGLRC DCPMGLELLN DMRTCVVPEA FLLFTNRADI
RSISLGTNSN DVAIPLTGVK EASALDFDVS ENRIYWTDVS TKTISRAFMN GSSVEHVIEF
GLDYPEGMAV DWMGRNVYWA DTGTNRIEVA RLDGQYRQVL VCKDLDNPRS LALNPANGYM
YWTEWGGKPR IARAHMDGSN IMTLVDKVGR ANGLTIDYID QRLYWTDLDT CMIESTNMQG
LQREIVADDL PHPFGLTQYR DYIYWTDWNL RSIERADKRS GLNRTMVQGH LEYVMDILVF
HSSRQDGAND CSQNNGNCAH LCLASPAGSQ CRCASHYILD SNSRNCSSPS SFLLFSQKAS
ISRMVLGEQS PDIILPIHVL RNVRAISYDP LDHLVYWVDG RQNIRRARDD GTQSSVVVST
TSTHQQQPDK QPHDLSLDTY SRTVYWTCEA TNTINLQRLD GDAVGVVLRD EHDKPRAIVV
NAEKGYMYFT TMQDRSAKIE GASLDGTERE SLFTTGLIRP VALALDNKLG KLFWVDADLK
RIESSDLTGA NRIVLQDSNI LQPMGLTVLG EHLYWIDRQQ QMIERVDKLI GEKRTRIQGR
IAYLTSIHAV EDMDPTEFAS HPCSRDNGGC SHICIAKGDG TPRCSCPMHL VLLPNLLICG
DPPTCSTEQF TCATGDIDCI PMAWRCDGVA ECDDNSDEEN CPMCSAIQFQ CDKGQCVDAQ
LRCNGEPDCA DNSDEQDCDT ICLPNQFRCN NKQCILKKQQ CDSYNDCADN SDELFCEFLT
PPSSDVQSPS HTSTIGPVIG IILSVFVMGG MYFVCQRVVC RRYKGPNGAF PHDYISGTSH
VPLNFISPSS SQHGTFTGIS CGKSMMSSVS LMGSSCSGAP LYDRNHVTGA SSSSSSSTKG
AFYPQMLNPP PSPATDRSLY NAEIFYSSNS PSTTRSYRPY LMHGVAPPTT PCSTDVCDSD
YATSRWKSNK YYMDLNSDSD PYPPPPTPRS QYLSAEESCP PSPSTERSYF HLCPPPPSPC
TDSS
//
