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Database: UniProt
Entry: A0A1S3MNJ9_SALSA
LinkDB: A0A1S3MNJ9_SALSA
Original site: A0A1S3MNJ9_SALSA 
ID   A0A1S3MNJ9_SALSA        Unreviewed;      1387 AA.
AC   A0A1S3MNJ9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=LOC106573896 {ECO:0000313|RefSeq:XP_014004808.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014004808.1};
RN   [1] {ECO:0000313|RefSeq:XP_014004808.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014004808.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC       protein kinase family. {ECO:0000256|ARBA:ARBA00009903}.
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DR   RefSeq; XP_014004808.1; XM_014149333.1.
DR   OrthoDB; 2915765at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa16.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd05609; STKc_MAST; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.20.1480.20; MAST3 pre-PK domain-like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000961; AGC-kinase_C.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR037711; MAST.
DR   InterPro; IPR015022; MAST_pre-PK_dom.
DR   InterPro; IPR023142; MAST_pre-PK_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24356:SF140; MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 3; 1.
DR   PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR   Pfam; PF08926; DUF1908; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF140482; MAST3 pre-PK domain-like; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_014004808.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          333..606
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          607..679
FT                   /note="AGC-kinase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51285"
FT   DOMAIN          875..963
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          967..1125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1304..1387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..726
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        727..758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        973..993
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1004..1045
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1055..1077
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1085..1125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1309..1324
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1387 AA;  154510 MW;  D7A6FE6FCC6CF165 CRC64;
     MQPLQPLTNP TSLELPEQQQ EESWRGDTVS HSVTPSLPTL RPHRAEGRRW SLASLPSSGY
     GTNPPSSTVS SSSSSQERLH QLPYQPTQDQ LHFLFKHFRS SENVADEEVR PSPFIRPRSH
     SLSPGRTMGS FDNEVVMMNH VYKERFPKAT VQMEERLLDI VTACSPDSTL PLSDGVLGFI
     QHQLVELVRD CLDKSHTGLV TSRYFVELQD KLEKLLHEAY DRSESEEVSV ITQLVKKILI
     IISRPARLLE CLEFDPEEFY HLLEAAEGHA KEGQGIKTDI PRYIINQLGL TRDPLEDMVQ
     LEQSAPSMTV KFDVEQNKCP QTPTRRKPLE SDFETIKLIS NGAYGAVYLV RHRNTRQRFA
     MKKINRQNLV LRNQIQQVFV ERDILTFAEN PFVVSMFCSF ETRRHLCMVM EYVEGGDCAN
     LLKNMGPLPV DMTRMYFAET VLALEYLHNY GIVHRDLKPD NLLITSMGHI KLTDFGLSRV
     GLMNMTTNLY EGHMEKDTRE FIDKQVCGTP EYIAPEVILR QGYGKPVDWW AMGVILYEFL
     VGCVPFFGDT PEELFGQVVS DDITWPDGDE ALPADAQDMI TRLLRQSPLE RLGTGGAPEV
     KQHPFFLHLD WNGLLRQKAE FIPQLEAEDD TSYFDTRSER YHHLASDEDD ETNDEESSLE
     IRQFSSWSNR LSKVYSSTEH LATPSNLSFS SGHSEDKEGW DGCFTPSPGG DIHRQERQHQ
     DRRGSLRPRA SSSSSQSERS ASPLVMSSTH SLETTPRFAF STDDEAEVVV SNLHRIRSNS
     TGAKHSSPKD HGASRRFGNQ LETPDRQTPD SPRLGGKLPK CASVSALSLV ITADDMLGGL
     QPSPILTRSL SSNPSSRDSS PSRDLSLSLS ILGPPIVIHS SGRKYGFTMQ AIRVYMGDSD
     VYTVHHMVSS VEYGSPAHEA GLRAGDLITH VNGESVQGLV HTEIMELLLK SGGKVALQTT
     ALENTSIKVG PARKTSHKGK MARRSKKSKR RDNQDRRRSV LKKLSKQSTV MHSSRSFNSG
     LQHHSVSSSE SLPGSPTHSL SPGPSTPCRS PAPDHQAGDT NSPQSTSPSS LHGLASKLGT
     QRYTKVGRRK STSSIPPSPL ACNSSTQPLS PQRSPSPLFG ITKTFHSKTL SPPTIVRHCL
     RPRSAEPPHS PLLKRVQSAE RLSSAYHTDK KSYPHRRHTL EVPFQDEVEG VCGRGDHGRL
     LVGYGGCQRL RDWASERSEQ LVVMRKLNLS ERRDSFKKQE AVQEVSFDEP DNQKTIPTVT
     ATTLNAPGGN RVPQRAASWT SISQTSEELT VVKRFNVVPQ IAVQGLTESE DQDDWEPCSD
     GEEDDGERQE PKYTDSNTAA GQGCLSHGKI SSKAPEVTAA LHKESPASDQ VGDTAVDSSP
     QKGKLRK
//
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