ID A0A1S3MNS3_SALSA Unreviewed; 1104 AA.
AC A0A1S3MNS3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Regulator of nonsense transcripts 1-like isoform X1 {ECO:0000313|RefSeq:XP_014004837.1};
GN Name=LOC106573910 {ECO:0000313|RefSeq:XP_014004837.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014004837.1};
RN [1] {ECO:0000313|RefSeq:XP_014004837.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014004837.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR RefSeq; XP_014004837.1; XM_014149362.1.
DR AlphaFoldDB; A0A1S3MNS3; -.
DR GeneID; 106573910; -.
DR KEGG; sasa:106573910; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000087266; Chromosome ssa16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF539; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 95..252
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 42..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..135
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 117..145
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 163..193
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 986..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 122339 MW; 3CD6740262F14E18 CRC64;
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEYEFTDFTL PSQTQTQGQT QSQLDNQVNG
PDEGLHNGGV DDVAKASQLL AELNFEEDEE DTYYIKDLPL HACSYCGIHD PASVVYCNTS
KKWFCNGRGN TSGSHIVNHL VRAKCKEVTL HKDGPLGETV LECYNCGCRN VFLLGFIPAK
ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS WLVKIPSEQE QLRARQITAQ
QINKLEELWK DNPTATLEDL EKPGVDEEPQ HVLLRYEDAY QYQNIFGPLV KLEADYDKKL
KESQTQDNIT VRWDLGLNKK RIAYFSLPKT DSGDMRLMQG DEICLRYKGE LAPLWKGIGH
VIKVPDTPFV KDYGDEIAIE LRSSVGAPVE IPHNFQVDFV WKSTSFDRMQ SALKTFAVDE
TSVSGYIYHK LLGHEVEDVI IKCQLPKRFT AQGLPDLNHS QVYAVKTVLQ RPLSLIQGPP
GTGKTVTSAT IVYHLARQGN GPVLVCAPSN IAVDQLTEKI HMSGLKVVRL CAKSREAIDS
PVSFLALHNQ IRNMDSMPEL QKLQQLKDET GELSSADEKR YRALKRTAER ELLMNADVIC
CTCVGAGDPR LAKMQFRSIL IDESTQATEP ECMVPVVLGA KQLILVGDHC QLGPVVMCKK
AAKAGLSQSL FERLVVLGIR PIRLQVQYRM HPALSAFPSN IFYEGSLQNG VTAADRIKKG
FDFQWPQPDK PMFFYVTQGQ EEIASSGTSY LNRTEAANVE KITTRLLKAG AKPDQIGIIT
PYEGQRSYLV QYMQFSGSLH TKLYQEVEIA SVDAFQGREK DFIILSCVRA NEHQGIGFLN
DPRRLNVALT RAKYGVIIVG NPKALSKQPL WNHLLNYYKE QKVLVEGPLN NLRESLMQFS
KPRKLVNAIN PGARFMSTAM YDAREALIPG SAYDRSSAGR PSNMYFQTHD QIGMIGAGPA
HMAAMNMPIP FNLVIPPMPP PGYLAQANGP AAGRGGVLKG KAGRGGRQRT RGMGNHSGSG
QSNGPNSQDV SSQPFSQGPL TQGYITMSQP SQMSQPGLSQ PELSQDSYLG DEFKSQIDVA
LSQDSTYQGE RAYQHGGVTG LSQY
//
