ID A0A1S3MPB4_SALSA Unreviewed; 1462 AA.
AC A0A1S3MPB4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=CD109 antigen-like {ECO:0000313|RefSeq:XP_014004930.1};
GN Name=LOC106573945 {ECO:0000313|RefSeq:XP_014004930.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014004930.1};
RN [1] {ECO:0000313|RefSeq:XP_014004930.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014004930.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014004930.1; XM_014149455.1.
DR GeneID; 106573945; -.
DR KEGG; sasa:106573945; -.
DR OrthoDB; 2970602at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF162; CD109 ANTIGEN; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1462
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010349869"
FT DOMAIN 477..605
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 701..792
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1323..1407
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT REGION 397..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 161794 MW; 931BD0756C59D4A3 CRC64;
MERIWLLGVC VALAVVSTSA QVSSSMSATY LISAPSVLRP GTPSSLAVTI LTNDPVRVTA
ELTNGNTSLV QAESTFTGGV TGVLDLPPFP ESSVDQRYSF KLLVRGYQRD RMVFINTTTL
RFNPRTFSTI IQTDKHNYRP GDTVKMRVLS VQPDGKPHKG RVYVSIRDPK GNLIQGWPSL
NSYLGVVSKE FHLSQTTPLG IWTIETMVDE LTTEEQFVVD YYEPPHFDVQ VKTAQEIVMV
DDLSGTVTAQ HTNGQPVQGT LSVTVTLVSA LFNSGRPTIV HNTTKDIHGS TQFLISQDDL
PVRQHRATYL SNSQHHTNGS LYITACVTEM STGLKTNKTV VVHVMENTYH LEFYNFPHVL
KPSLNFSSHL KISRYDNDPL TPEDRMNSVF IDIGHRTSKP IGQNQGETIS DSPQDKKEDI
KSYRRLTLSV PEDGIVHIEF QLHKQVEMLF IQAMFMGSEE SLELYNSNHS SPSGSYIQIQ
RLHSPPQIGK PLPISVESTF QLTELHYLVT SRGQVVAART ATSPSFSLTP AVSWSPEACV
TVFCVLPDGE IINDAMHVFI KPHGVLQNEV YLSWSHEKVM PGEEVSLTVL VIEPGSLVGI
MVVAMEGKDS DSDGDITEEK VLVEMTDYLK EDITLHHSGI TGGKDSPLSV FTACNLVVLT
DASLHKTEDY QETEMDHEAE ALMRKDQPEW RPSMGQDFSK TWLWLDMNIS ESTTTSFHVA
VPDSITSWRA MAFVMSDNLG LGLTFKPQKL IVSTDFSLSL DVPECITRGE QLVLEVNLFN
HLEEDTEVIV VVAESSRFEF VLADRDLVSM VNARRVTVGS QGGATALFPI RPLVFGEILM
SVKAMTGQAT KKIVRKVLVK PEGKEQSFSE TVFLEVVLTN RNLSRQLHFS FPPDVVPGSE
RAHVAVVGDI LGLSITGLGL LVKMPHGCGE QNMINFAPNV YVLQRLAKSS QPYEEIRSKA
LSYMMEGYQR ELSFQRDDGS FSAFGASDTS GSTWLTAFVL RCFLQARSFM QIDQSVLSRA
MAWLVQQQGS QGEFIEMGRV IHTELQGGLD GPVSLTSYVL VTLLEDQAYV NMFPGNVSLT
RSYLEGEVAS GVSSNYSLCL AAYALSLANS LTAGTALDEL KRRADIRDGV QTWRSSSAEV
SDSWQPRSAE IEMAAYVLLA LYKRASVVEA ISLMKWLSQQ RNYLGAYGST QDTVVALQAL
SVYATFSGAH AIELGVEVST SVSPTVSHFH INSTNYLVHQ SKEVDAEQDL LINVFMEGRG
FALFQMNVFY NIEDRVLSER SQDDTVHEGF SLDVEVLDDE DDLDHIMLSI CTRLLESQKI
AQTGMVLVDV GVLSGFTLAP QAVATGDLVR KVEASPGKVN LYLDSLTATQ VCIRIPMIRD
FKVSHVQDAV VQVYDYYEPR RKAVRSYNSD VMQHMGSCAF CGRDCGLCRQ EIIISSSSTA
HTKNTAIYWL GCVLVAIIAL LL
//
