ID A0A1S3MS65_SALSA Unreviewed; 858 AA.
AC A0A1S3MS65;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Multidrug resistance protein 1-like {ECO:0000313|RefSeq:XP_014006073.1};
GN Name=LOC106574611 {ECO:0000313|RefSeq:XP_014006073.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014006073.1};
RN [1] {ECO:0000313|RefSeq:XP_014006073.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_014006073.1; XM_014150598.1.
DR AlphaFoldDB; A0A1S3MS65; -.
DR KEGG; sasa:106574611; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24222; ABC TRANSPORTER B FAMILY; 1.
DR PANTHER; PTHR24222:SF76; MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTA; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 56..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..359
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 394..630
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 714..829
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT REGION 15..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 858
FT /evidence="ECO:0000313|RefSeq:XP_014006073.1"
SQ SEQUENCE 858 AA; 94900 MW; 8BF3D5A28ED92D47 CRC64;
MSKKDEIALA KVKIEQNGDI GEDKDEEKKG EKEKEPKMPM IGAIALFRFA DGWDRWMIVL
GTIMAMVNGT VLPLMCIVFG DMTDSFIEDS IQTQNNFTNI TFPVSNTTLG EEMTGHAIYY
SIMGAVVLVA AYMQVAFWTL AAGRQVKRLR KLFFHCIMQQ EIGWFDINET GELNTRLTDD
IYKINEGIGD KVGMLIQSFT TFIASFIIGF SKGWKLTLVI LAVSPVLGFS AFIFSKVLTS
FTSLEQSAYA KAGAVAEEVI SSVRTVFAFG GQQKEITRYQ KNLEDAKNMG IRKAISANIA
MGFTFLMIYL SYALSFWYGS TLILSGEYTI GTVLTVFFTV LIGAFAMGQT SPNVQAFASA
RGAAHKVYNI IDNKPHINSY SDHGHKPDVI KGNIEFNNIH FTYPSRPDVK VLNGMSLSVR
SGQTIALVGS SGCGKSTTVQ LLQRFYDPQE GSVCVDGHDV RSLNVRFLRE MIGVVSQEPI
LFATTIAENI RYGRPDVTHQ EIEQAAREAN AYDFIMTLPD KFETLVGDRG TQMSGGQKQR
IAIARALVRN PKILLLDEAT SALDAESETI VQAALDKVRQ GRTTIVVAHR LSTIRNADVI
AGFQKGEIVE LGTHSQLMEK KGVYHTLVTM QTFKSPEEGK EAVEEQVLEG KSPSVTPFSE
TTLIRRKSTK GSSFIGSEKG DKDKTEVEEE DEEIPPVSFL KVLKLNLPEW PYMVVGVICA
TINGGMQPLF AVIFSKIVAV FAEQDQELVR QRSSFYSIMF AFIGVVSFIT MFLQGFCFGK
AGEILTMKLR LMAFKAMMRQ ELGWYDSHKN SVGALTTRLA TDAAQVQGVG SKYTHEHNAH
THSNPPSLPL QATGVRLA
//
