ID A0A1S3MS73_SALSA Unreviewed; 1104 AA.
AC A0A1S3MS73;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Nardilysin-like {ECO:0000313|RefSeq:XP_014006037.1};
GN Name=LOC106574586 {ECO:0000313|RefSeq:XP_014006037.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014006037.1};
RN [1] {ECO:0000313|RefSeq:XP_014006037.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR RefSeq; XP_014006037.1; XM_014150562.1.
DR AlphaFoldDB; A0A1S3MS73; -.
DR KEGG; sasa:106574586; -.
DR Proteomes; UP000087266; Chromosome ssa16.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 148..277
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 303..488
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 494..775
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 781..961
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..136
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 125617 MW; 00C362AB3727A779 CRC64;
MPQTSKVNNS AAGGPGQVSA PDHGEPPPPQ AEPRDLASGD GGVGVDEDQG DLQINKSPSD
PKKYRYIELT NGLRVLLISD FSGADGKDAC REEEEEEDGA SGGGEEAEEE GDSGEGTEEE
DEDAEEEHDS DFEELDEEQE GKQKKGSSEK QSAAALCISV GSFSDPEDLP GLAHFLEHMV
FMGSEKYPAE NGFDAFLKKH GGSDNASTDC ERTIFQFDVQ RKYFREALDR WAQFFICPLM
IEDAIDREVE AVDSEYQLAR PSDSHRKEML FGSLARPKHP MGKFCWGNAQ TLKHEPREKQ
INTYQRLRDF WKRYYSAHYM TLTVQSKETL NTLEEWVREV FSKVPNNAQP RPDFSDLQDP
FDTPTFNKLY RIVPVRKVHA LTVTWALPPQ GKQYRVKPLH YISWLIGHEG AGSILSLLRK
KCWALALFGG NSETGFDQNS TYSIFSISIT LTDQGFQNFY QVAHLVFQYL KMLQSLGPQQ
RIYEEIQKIE ANEFHYQEQT DPIEYVEDIC ENMQLFPKEH FLTGDQLMFQ YSPEVISAAL
SLLTPDRSNL LLLSPDHEGH CPLREKWFGT HYSVEDIQQE WRERWNGDLE LSSELHLPVE
NKFIATDFSL KQSDCPDTDL PVRVTANDRG CLWYKKDNKF NIPKAYIRFH LISPVIQQSA
KNLVLFDLLV NILGHNLAEP AYEADVAQLD YKLSVGEHGL VIKVKGFNHK LPLLFHLILD
HLADFSACQD VFSMFSEQLK KTYFNILIRP EKLGKDVRLL VLEHGRWSMV EKYQALADGG
LTVEELMEFS RTFKTQLYAE GLVQGNFTSQ ESIQFLQYIT DKLQFSKLPA EVPVLFRVVE
LPLKQHLCKV KALNKGDANS EVTVYYQSGL KNLREHTLME LLVMHMEEPC FDFLRTKETL
GYHVYPTCRN TSGVLGFSVT VETQATKFNT ELVELKIEEF LSSFGEKLSA LTESAFNTQV
TALVNLKECE DTHLGEEVDR NWAEVATQQY VFNRLHREIE ALKQMTRAEL VSWYLEHRGH
NCRKLSVHVV GFGPEEGDPP GDDKQSRRGN GERDEEESGS SSYGEVSKLT FLPASPKMAA
ATAIMDIPSF TQSLTLFPYH KIIQ
//
