ID A0A1S3MTJ3_SALSA Unreviewed; 807 AA.
AC A0A1S3MTJ3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Rho guanine nucleotide exchange factor 7-like isoform X4 {ECO:0000313|RefSeq:XP_014006096.1};
GN Name=LOC106574627 {ECO:0000313|RefSeq:XP_014006096.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014006096.1};
RN [1] {ECO:0000313|RefSeq:XP_014006096.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014006096.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014006096.1; XM_014150621.1.
DR AlphaFoldDB; A0A1S3MTJ3; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000087266; Chromosome ssa16.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003096; SM22_calponin.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 163..222
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 250..430
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 452..557
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 562..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 755..796
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 562..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 90942 MW; 29055C12B13EB29B CRC64;
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQSSLKDGVV LCKLVERLRP GSVEKIFQEP
RNDSEFQSNI KEFLKGCGSF RVEPFEVNDL LQGLNFTKVL NSLVALAKAT EDIGVGSDSV
CAHHSSSLRI KSFDSLNTQS PRGRSSKLLH NQYRSLDMSE SGGQRVLVKA KFTFQQTNED
ELSFNKGDMI SVSRQEDGGW WEGSFNGNKG WFPSNYVKEV KGSDKPVSPK SGTLKNPVKG
FDTPAVSKTY YNLVLQNILE TEIEYSKKLQ NLLTSYLHSL QPTDKLSSAD VSHILGNLED
ISTFQLMLVQ SYEECTKLPE SQQRVGGFFL NLLPQMKALY MAYCSNHPSA VNVLTEHSEE
LGEFMEGKGA SSPGILTLTT GLSKPFMRMD KYPTLLKELE RHMEEHHPDR PDIQKCLTSF
KSLSAQCQEV RKRKELELQI LTETIRRWEG DDIRTLGPVL YMSHTLCHTH GSEEKSERYL
LLFPNVLLLL SASSRMSGFI YQGKLPLTGM LISRIEDCEM VKNAFEISGS TCERMQVVCN
NQQDLQEWVE HLSRHTQIRN APSGIMTTPT AKPQSVPCHT LPSHPLTPSR HSESRGVSGG
PAYHTLPHPS SHGVPQTPPM WGPLEPPCTP KPWSLSCLRP APPLKPSAAL CYKEDLSKSP
KSMKKLLPKR KPERKPSDED FATRKSTAAL EEDAQILKVI EAYCTSAKTR QTLNSRSREK
SGLHMLFPEE EKIIVEETKS NGQTVIEEKT LVDTVYGLKD EVQELKQDNK KMRRTLDEEQ
KARKELEKIL RRVLKNMNDP TWDETNL
//
